- Models of Investigation
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41 min
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44 min
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38 min
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62 min
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61 min
- Cell Types and Recruitment
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71 min
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51 min
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42 min
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63 min
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25 min
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61 min
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41 min
- Recognition and Signaling
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50 min
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42 min
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39 min
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44 min
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38 min
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41 min
- Modulation of Effector Responses
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22 min
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42 min
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54 min
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39 min
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38 min
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69 min
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42 min
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27 min
- Pathogen-Host Interactions
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46 min
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50 min
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56 min
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53 min
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34 min
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51 min
- Health and Disease
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39 min
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59 min
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33 min
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38 min
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36 min
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54 min
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49 min
- Archived Lectures *These may not cover the latest advances in the field
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73 min
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32 min
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51 min
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39 min
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63 min
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35 min
Topics Covered
- Plasmacytoid dendritic cells (pDCs) are important mediators of antiviral immunity through their ability to produce large amounts of type I interferons (IFNs) on viral infection
- This function of pDCs is linked to their expression of Toll-like receptor 7 (TLR7) and TLR9, which sense viral nucleic acids within the early endosomes
- Exclusion of self nucleic acids from TLR-containing early endosomes normally prevents pDC responses to them
- In some autoimmune diseases, self nucleic acids can be modified by host factors and gain entrance to pDC endosomes, where they activate TLR signaling
- Several pDC receptors negatively regulate type I IFN responses by pDCs during viral infection and for normal homeostasis
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Liu, Y. (2009, June 30). Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity [Video file]. In
The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved May 29, 2023, from
https://hstalks.com/bs/1289/.
Export Citation (RIS)
Publication History
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Published on June 30, 2009
Financial Disclosures
- Prof. Yong-Jun Liu has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.