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- Models of Investigation
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1. Antifungal innate immunity in C. elegans
- Dr. Jonathan Ewbank
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2. The anti-microbial defense of Drosophila: a paradigm for innate immunity
- Prof. Jules Hoffmann
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3. Phagocytosis in the fruit fly, Drosophila melanogaster
- Dr. Lynda Stuart
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4. Innate immune sensing and response
- Prof. Bruce Beutler
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5. Macrophages and systems biology
- Prof. David Hume
- Cell Types and Recruitment
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6. Leukocyte recruitment in vivo
- Prof. Paul Kubes
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8. Eosinophils
- Prof. Tim Williams
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9. Dendritic cells: linking innate to different forms of adaptive immunity
- Prof. Ralph Steinman
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11. Innate-like lymphocytes 1
- Prof. Adrian Hayday
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12. Innate-like lymphocytes 2
- Prof. Adrian Hayday
- Recognition and Signaling
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13. Colony stimulating factor-1 regulation of macrophages in development and disease
- Prof. E. Richard Stanley
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14. Fc receptors: linking innate and acquired immunity
- Prof. Ken G C Smith
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15. Phagocytosis
- Prof. Joel Swanson
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16. Clearance of apoptotic cells and the control of inflammation
- Prof. Sir John Savill
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17. Signaling by innate immune receptors
- Prof. Michael Karin
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18. Nuclear receptors at the crossroads of inflammation and atherosclerosis
- Prof. Christopher Glass
- Modulation of Effector Responses
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19. Humoral innate immunity and the acute phase response 1
- Prof. Alberto Mantovani
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20. Humoral innate immunity and the acute phase response 2
- Prof. Alberto Mantovani
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21. Cytokines regulating the innate response
- Prof. Anne O’Garra
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22. Arginase and nitric oxide
- Dr. Peter Murray
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23. Novel lipid mediators in resolution of inflammation
- Prof. Charles Serhan
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25. Cationic peptides in innate immunity
- Dr. Dawn Bowdish
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26. Iron metabolism and innate immunity
- Prof. Tomas Ganz
- Pathogen-Host Interactions
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27. Innate recognition of viruses
- Prof. Caetano Reis e Sousa
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28. Type I interferons in innate immunity to viral infections
- Prof. Christine Biron
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29. HIV-1 and immunopathogenesis: innate immunity
- Prof. Luis Montaner
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30. Understanding and combating tuberculosis
- Prof. David Russell
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32. Innate immunity and malaria
- Prof. Douglas Golenbock
- Health and Disease
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33. Innate immunity in children
- Prof. David Speert
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34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis
- Prof. Sir Ravinder Maini
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35. NOD-like receptors in innate immunity and inflammatory disease
- Prof. Gabriel Nunez
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36. Paneth cells in innate immunity and inflammatory bowel disease
- Prof. Satish Keshav
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37. Innate immunity in the brain in health and disease
- Prof. V. Hugh Perry
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38. The fate of monocytes in atherosclerosis
- Prof. Gwendolyn Randolph
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39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis
- Prof. Jeffrey Pollard
- Archived Lectures *These may not cover the latest advances in the field
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40. Monocyte/macrophages in innate immunity
- Prof. Emeritus Siamon Gordon
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41. Innate immunity in C. elegans
- Dr. Jonathan Ewbank
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43. NLR genes: infection, inflammation and vaccines
- Prof. Jenny Ting
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44. Manipulation of innate immune response: lessons from shigella
- Prof. Philippe Sansonetti
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45. Innate immunity of the lung and adaptation to air breathing at birth
- Prof. Jeffrey Whitsett
Printable Handouts
Navigable Slide Index
- Introduction
- Pathologists (1958 to 1980s)
- Virologist, Immunologists (1970s)
- Identification of plasmacytoid DC
- Isolation of human plasmacytoid pre-DCs
- Electron microscopy of plasmacytoid DC
- Plasmacytoid DC is an interferon producing cell
- Kinetic of pDCs to produce type 1 IFNs
- pDC's new transcription during anti-viral response
- Repertoire of type 1 IFN response by pDCs
- pDC as innate effector cell against viral infection
- Can IPC/pDC be generated from stem cells?
- Localization of pDC and mDC
- Linking innate and adaptive immunity - pDC/IPC
- The functions of pDC
- TLR expression by pDC and mDC
- pDC sense viral DNA and RNA
- pDC-sense self-DNA in autoimmune diseases
- Factors capable of binding self-DNA
- Microarray of human immune cells
- pDC receptors
- ILT7 and BDCA2 are two pDC specific receptors
- Hematopoietic immune receptors
- Human pDCs express 3 transmembrane adaptors
- ILT7 associates with Fc-epsilon-R1-gamma
- ITAM signaling
- Inhibition of TLR responses in pDCs
- Summary
- ILT7 reporter cell system
- Breast cancer cell lines express an ILT7 ligand
- Generate mAb to identify ILT7 ligand (1)
- Generate mAb to identify ILT7 ligand (2)
- Identify ILT7 ligand
- Characterizing BST2
- BST2 negatively regulate pDC's IFN response
- Acknowledgements
Topics Covered
- Plasmacytoid dendritic cells (pDCs) are important mediators of antiviral immunity through their ability to produce large amounts of type I interferons (IFNs) on viral infection
- This function of pDCs is linked to their expression of Toll-like receptor 7 (TLR7) and TLR9, which sense viral nucleic acids within the early endosomes
- Exclusion of self nucleic acids from TLR-containing early endosomes normally prevents pDC responses to them
- In some autoimmune diseases, self nucleic acids can be modified by host factors and gain entrance to pDC endosomes, where they activate TLR signaling
- Several pDC receptors negatively regulate type I IFN responses by pDCs during viral infection and for normal homeostasis
Talk Citation
Liu, Y. (2009, June 30). Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 12, 2024, from https://doi.org/10.69645/MEGI4877.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Yong-Jun Liu has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity
Published on June 30, 2009
25 min
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