Topics Covered
- Sensing infection is essential to the initiation of an immune response
- The innate immune system senses signature molecules made by microbes using a conserved set of germline-encoded receptors
- This receptor family (the Toll-like receptors) was first understood when a mutation that abolished lipopolysaccharide (LPS) sensing was positionally cloned in mice
- In Drosophila a homologous receptor is also used to detect infection, and still another receptor activates a pathway evocative of the tumor necrosis factor (TNF) pathway in mammals
- Further work in mammals has depended upon gene targeting and also forward genetic work, which has revealed many of the components of the TLR signaling apparatus
- Forward genetics has also allowed us to see how many genes (and what kinds of genes) are important for resisting an infection in vivo
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Talk Citation
Beutler, B. (2009, May 31). Innate immune sensing and response [Video file]. In
The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved September 28, 2023, from
https://hstalks.com/bs/1281/.
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Publication History
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Published on May 31, 2009
Financial Disclosures
- Prof. Bruce Beutler has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.