• Models of Investigation
• 41 min
  1. Antifungal innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 44 min
  2. The anti-microbial defense of Drosophila: a paradigm for innate immunity

  • Prof. Jules Hoffmann
• 38 min
  3. Phagocytosis in the fruit fly, Drosophila melanogaster

  • Dr. Lynda Stuart
• 62 min
  4. Innate immune sensing and response

  • Prof. Bruce Beutler
• 61 min
  5. Macrophages and systems biology

  • Prof. David Hume
• Cell Types and Recruitment
• 71 min
  6. Leukocyte recruitment in vivo

  • Prof. Paul Kubes
• 51 min
  7. Chemokines and inflammation: a critical assessment of therapeutic targets

  • Dr. David Greaves
• 42 min
  8. Eosinophils

  • Prof. Tim Williams
• 63 min
  9. Dendritic cells: linking innate to different forms of adaptive immunity

  • Prof. Ralph Steinman
• 25 min
  10. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity

  • Prof. Yong-Jun Liu
• 61 min
  11. Innate-like lymphocytes 1

  • Prof. Adrian Hayday
• 41 min
  12. Innate-like lymphocytes 2

  • Prof. Adrian Hayday
• Recognition and Signaling
• 50 min
  13. Colony stimulating factor-1 regulation of macrophages in development and disease

  • Prof. E. Richard Stanley
• 42 min
  14. Fc receptors: linking innate and acquired immunity

  • Prof. Ken G C Smith
• 39 min
  15. Phagocytosis

  • Prof. Joel Swanson
• 44 min
  16. Clearance of apoptotic cells and the control of inflammation

  • Prof. Sir John Savill
• 38 min
  17. Signaling by innate immune receptors

  • Prof. Michael Karin
• 41 min
  18. Nuclear receptors at the crossroads of inflammation and atherosclerosis

  • Prof. Christopher Glass
• Modulation of Effector Responses
• 22 min
  19. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  20. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 54 min
  21. Cytokines regulating the innate response

  • Prof. Anne O’Garra
• 39 min
  22. Arginase and nitric oxide

  • Dr. Peter Murray
• 38 min
  23. Novel lipid mediators in resolution of inflammation

  • Prof. Charles Serhan
• 69 min
  24. Resolvins activate inflammation-resolution programs: a systems approach to resolution

  • Prof. Charles Serhan
• 42 min
  25. Cationic peptides in innate immunity

  • Dr. Dawn Bowdish
• 27 min
  26. Iron metabolism and innate immunity

  • Prof. Tomas Ganz
• Pathogen-Host Interactions
• 46 min
  27. Innate recognition of viruses

  • Prof. Caetano Reis e Sousa
• 50 min
  28. Type I interferons in innate immunity to viral infections

  • Prof. Christine Biron
• 56 min
  29. HIV-1 and immunopathogenesis: innate immunity

  • Prof. Luis Montaner
• 53 min
  30. Understanding and combating tuberculosis

  • Prof. David Russell
• 34 min
  31. The taste of a fungus: recognition of Candida by the innate immune system

  • Prof. Neil Gow
• 51 min
  32. Innate immunity and malaria

  • Prof. Douglas Golenbock
• Health and Disease
• 39 min
  33. Innate immunity in children

  • Prof. David Speert
• 59 min
  34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis

  • Prof. Sir Ravinder Maini
• 33 min
  35. NOD-like receptors in innate immunity and inflammatory disease

  • Prof. Gabriel Nunez
• 38 min
  36. Paneth cells in innate immunity and inflammatory bowel disease

  • Prof. Satish Keshav
• 36 min
  37. Innate immunity in the brain in health and disease

  • Prof. V. Hugh Perry
• 54 min
  38. The fate of monocytes in atherosclerosis

  • Prof. Gwendolyn Randolph
• 49 min
  39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis

  • Prof. Jeffrey Pollard
• Archived Lectures *These may not cover the latest advances in the field
• 73 min
  40. Monocyte/macrophages in innate immunity

  • Prof. Emeritus Siamon Gordon
• 32 min
  41. Innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 51 min
  42. Antigen processing and presentation: modulation by innate immune signals

  • Prof. Colin Watts
• 39 min
  43. NLR genes: infection, inflammation and vaccines

  • Prof. Jenny Ting
• 63 min
  44. Manipulation of innate immune response: lessons from shigella

  • Prof. Philippe Sansonetti
• 35 min
  45. Innate immunity of the lung and adaptation to air breathing at birth

  • Prof. Jeffrey Whitsett

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Insects are prone to many types of infections
3. Insect host defense is a multifacetted process
4. Induction of antimicrobial activity
5. Systemic antimicrobial response in Drosophila
6. NF-kappaB-response elements in Drosophila
7. Two types of NF-kappaB family members
8. Gene cascade controlling the dorso-ventral axis
9. Toll controls drosomycin but not diptericin
10. Imd mutants are sensitive to bacterial infections
11. Toll mutants are sensitive to fungal infections
12. Overwhelming fungal infection in a Toll mutant
13. Toll as an IL-1R and CD-14 chimera
14. TLR family members and their ligands
15. NF-kappaB activation in Drosophila
16. Semmelweis and anti-gram-positive defense
17. Structural aspects of PGRPs
18. Peptidoglycan and the roles of PGRPs
19. Immune responses to different pathogens
20. NF-kappaB activation by Toll in Drosophila
21. NF-kappaB activation by IMD in Drosophila
22. The response of Drosophila to virus infection
23. Drosophila responses to RNA virus infections (1)
24. Drosophila responses to RNA virus infections(2)
25. Role of the mosquito immune system
26. Levels of Plasmodium in A. gambiae
27. The immune response can kill the Plasmodium
28. Cactus depletion aborts Plasmodium development
29. Plasmodium abortion rescued by Rel1 knockdown
30. Thioester-containing protein 1 in A. gambiae
31. Parasite survival in TEP1 transgenic mosquitoes
32. Phylogeny of NF-kappaB
33. Signaling cascades: Drosophila and mammals
34. Acknowledgements
35. Credits: Drosophila immunity

Topics Covered

• The insect host defense is a multifaceted process
• Systemic anti-microbial response in Drosophila
• NF-kB: a central transactivator in immune responses
• Gene cascade
• The Toll pathway
• Imd pathway mutants are sensitive to bacterial infections
• Toll pathway mutants are sensitive to fungal infections
• TLR family members and their ligands
• The semmelweis (seml) mutation compromises the anti-gram-positive defense
• Structural aspects of PGRPs
• NF-kB activation by Toll and IMD in Drosophila
• Investigating the response of Drosophila to virus infection
• Response to RNA virus infections
• Keeping parasite numbers low: role of the mosquito immune system
• Losses and amplification of Plasmodium in A. gambiae
• Cactus
• ThioEster-containing Protein 1 (TEP1)

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Publication History

• Published on May 31, 2009

Financial Disclosures

• Prof. Jules Hoffmann has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.