Biomedical Basics

Fluid balance and electrolyte homeostasis

  • Created by Henry Stewart Talks
Published on October 30, 2025   4 min

A selection of talks on Gastroenterology & Nephrology

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The topic of Fluid Balance and Electrolyte Homeostasis will be explored through fluid compartments and their roles, the essential electrolytes and how they regulate cellular and physiological activity, and the movement of water and solutes between compartments. We’ll explain how the kidneys and hormones maintain this balance, and discuss the consequences of disruptions such as dehydration, hyponatremia, and hypernatremia. Understanding these principles is key to recognizing and managing fluid and electrolyte disorders effectively.. Fluid balance and electrolyte homeostasis are essential for healthy body function, maintaining correct fluid volume and composition in different compartments. Bodily fluids are distributed in two main areas: intracellular fluid, inside cells, which accounts for about two-thirds of total body water, and extracellular fluid, outside cells, making up the remaining third. Extracellular fluid is divided into plasma—the fluid part of blood—and interstitial fluid, which surrounds cells. The equilibrium between these compartments is crucial for normal cellular activity and physiological stability. Electrolytes like sodium, potassium, and chloride are essential for fluid and electrolyte balance. Sodium is the main extracellular cation, potassium is mainly inside cells, and chloride usually accompanies sodium outside cells. These ions control osmotic gradients, water movement, and the electrical activity for nerve impulses and muscle contractions.

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