We noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Topics
- Ectopic fat
- Framework of organs interaction (1)
- Topics - consequences of excess lipid storage
- Consequences of 'ectopic' fat
- Lipid oversupply is also referred to as lipotoxicity
- Ectopic fat and insulin resistance
- Intramyocellular distribution of lipid droplets
- Skeletal muscle lipid content
- The obese and endurance-trained paradox
- IMCL content and insulin sensitivity
- Two routes to increased intramyocellular lipid
- Ectopic fat and the beta cell (1)
- 'Starling curve' of the pancreas
- New beta cells are constantly being created
- Apoptosis is a major factor of beta-cell failure (1)
- Apoptosis is a major factor of beta-cell failure (2)
- Ectopic fat and the beta cell (2)
- Ectopic fat and the liver
- Liver fat and hepatic insulin resistance
- Hepatic lipid content related to insulin sensitivity
- Consequences of hepatic steatosis
- Topics - causes of ectopic fat
- Adipose tissue 'dysfunction'
- Consequences of increased adipose tissue mass
- The 'adipokine' secretion pattern changes
- Signal molecules secreted by adipose tissue
- Adipose tissue 'inflammation'
- Number of fat cells and the energy 'burden'
- Large fat cells - a marker of insulin resistance
- Risk factors for type 2 diabetes
- Transgenic animal models support Danforth theory
- Visceral fat is the 'other' ectopic adipose tissue
- Fat pattern in female and risk of type 2 diabetes
- Adipose tissue is a complex organ
- Waist circumference
- Abdominal adipose tissue - nomenclature
- Subcutaneous adipose tissue
- Topics - impairments in fat oxidation
- Response of the tissues to increased lipid supply
- Insulin resistance and muscle ATP synthesis
- Rationale for the study of muscle mitochondria
- Reduced mitochondrial volume in T2DM
- Pre-clinical models
- Topics - ectopic fat treatment
- Framework of organs interaction (2)
- Modest weight loss reverses ectopic fat
- Exercise vs. weight loss
- Framework - TZDs and 'ectopic' fat
- Treatment
- TZD's and ectopic lipid
- TZDs decrease liver fat
- Pio increases insulin sensitivity and adiponectin
- FFA reductions are sufficient to reduce lipotoxicity
- Summary
- Thank you
- Acknowledgements
Topics Covered
- Definition of ectopic fat
- Consequences of ectopic fat
- Insulin resistance
- Beta cell failure
- Increased VLDC cholesterol production / atherogenic dyslipidemia
- Adipose tissue dysfunction
- Adipose tissue inflammation
- An inadequate number of fat cells compared to the energy 'burden'
- Large fat cells
- insulin resistance
- Transgenic animal models
- Visceral fat is the 'other' ectopic adipose tissue
- Adipose tissue is a complex organ
- there is still room for discovery at many levels
- Waist circumference
- Abdominal adipose tissue; nomenclature
- Subcutaneous adipose tissue: radiographic considerations
- The study of muscle mitochondria
- Pre-clinical models
- Modest weight loss reverses ectopic fat
- Exercise vs. weight loss
- Treatment
- TZD's and ectopic lipid
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Smith, S. (2009, April 30). Ectopic fat: causes, consequences and treatment [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 9, 2024, from https://doi.org/10.69645/HHVS7553.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Steven Smith has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.