On Sunday, April 20th 2025, starting 8:30am GMT, there will be maintenance work that will involve the website being unavailable during parts of the day. We apologize for any inconvenience this may cause and appreciate your understanding.
We noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- Evolutionary Perspectives
-
1. Antibiotic resistance: a mechanistic overview
- Dr. Neil Woodford
-
2. Mutation
- Prof. Stephen Gillespie
-
3. Fitness in antibiotic resistant bacteria
- Prof. Stephen Gillespie
-
4. Fitness and compensation
- Dr. Sébastian Gagneux
-
5. Antibiotic resistance and the supragenome hypothesis
- Dr. Bambos Charalambous
- Epidemiology and Clinical Impact
-
6. Methicillin resistant S. aureus and other resistances
- Prof. Mark Enright
-
7. Risk factors for antibiotic resistance in Streptococcus pneumoniae
- Prof. Keith Klugman
-
8. Beta-lactamases: clinical impact and epidemiology
- Prof. Sebastian Amyes
-
9. Glycopeptide-resistant enterococci
- Dr. Neil Woodford
-
10. Drug resistant tuberculosis: biology, epidemiology and control
- Dr. Christopher Dye
-
11. Antiretroviral drug resistance
- Prof. Deenan Pillay
-
12. Malaria - changing paradigms
- Dr. Janet Cox-Singh
-
13. Advances in mode of action of antimalarials and resistance mechanisms 1
- Prof. David Warhurst
-
14. Advances in mode of action of antimalarials and resistance mechanisms 2
- Prof. David Warhurst
- Diagnosis and Surveillance of Resistance
-
15. Conventional and automated diagnostic methods
- Dr. Alan Johnson
-
16. National and international surveillance of antibiotic resistance 1
- Prof. David Livermore
-
17. National and international surveillance of antibiotic resistance 2
- Prof. David Livermore
-
18. Innovative approaches to rapid antibiotic resistance testing
- Dr. Robert Hammond
- Controlling Antibiotic Resistance
-
19. Controlling antibiotic resistance in the hospital environment
- Dr. Ian Eltringham
-
20. Controlling antibiotic resistance in the community
- Dr. Peter Wilson
-
21. Public policy to reduce antibiotic resistance
- Dr. Niels Frimodt-Møller
- The Antibiotic Resistance Future
-
22. Overcoming resistance through novel drug targets
- Prof. Anthony Coates
-
23. Medicinal chemistry strategies in combating antibiotic resistance
- Dr. Geoffrey Coxon
-
24. Teixobactin kills pathogens without detectable resistance
- Prof. Kim Lewis
- Archived Lectures *These may not cover the latest advances in the field
-
25. Molecular diagnosis of antibiotic resistance
- Dr. Tim McHugh
-
26. Introduction to malaria
- Prof. David Warhurst
Printable Handouts
Navigable Slide Index
- Introduction
- Mechanisms of antibiotic action
- Resistance is as old as antibiotics
- Antibiotic resistance mechanisms
- Types of resistance
- Defining resistance
- Susceptibility is an interplay of multiple factors
- Antibiotics select resistant bacteria
- Bacteria carry resistance in their DNA
- Resistance is transferred (1)
- Resistance is transferred (2)
- The Red Queen Principle
- Resistance is inevitable
- How quickly does resistance emerge?
- Oxazolidinone timeline
- Mechanism 1: alteration of the target
- The forensics of antibiotic resistance
- Epidemiological investigation of resistance
- Surveillance of resistance
- An example of a trend noticed in surveillance
- Mechanism 2: metabolic by-pass
- Cephalosporin-resistant E. coli
- Why might resistance rates rise?
- Understanding rising prevalence
- Mechanism 3: drug destruction
- Global explosion of CTX-M ESBLs
- Multi-resistance plasmids
- The use of carbapenems
- Mechanism 4: reduced uptake
- Restore porins and reverse carbapenem resistance
- Carbapenemase-mediated resistance in the UK
- The OXA-23 clone 1
- Mechanism 5: up-regulated efflux
- Recap: mechanisms of resistance
- Undefined mechanism of action
- Undefined resistance mechanisms
- Summary
- Acknowledgements
Topics Covered
- Modes of antibiotic action
- Modes of resistance
- Intrinsic / acquired resistance
- Emergence and transfer of resistance
- Monitoring spread
- Modified targets
- Enzymic destruction
- ESBLs
- Plasmidic multi-resistance
- Impermeability / porin loss
- Carbapenemases
- Efflux pumps
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Woodford, N. (2009, December 31). Antibiotic resistance: a mechanistic overview [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 17, 2025, from https://doi.org/10.69645/CWUB4965.Export Citation (RIS)
Publication History
- Published on December 31, 2009
Financial Disclosures
- Dr. Neil Woodford has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.