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Printable Handouts
Navigable Slide Index
- Introduction
- Talk outline
- Protein targeting
- Protein targeting and secretion in E. coli
- SRP-mediated targeting
- Conservation of the SRP/SR
- Cryo-EM structure of ribosome-SRP complex
- Co-translational targeting by the SRP
- Specific aspects of E. coli SRP
- Trigger factor
- SecYEG
- Crystal structure of the Sec-translocon
- Biogenesis of two model E. coli IMPs
- The model proteins
- In vitro translation and cross-linking
- Studying FtsQ and Lep
- Cross-linking 108FtsQ
- A dual role of YidC in IMP integration
- Properties of YidC
- Interactions in FtsQ membrane integration (1)
- Interactions in FtsQ membrane integration (2)
- Membrane integration of Lep H1
- Two models of membrane integration
- Rapid movement of H1 into lipid bilayer
- Membrane integration of Lep H2
- Membrane integration of Lep - summary
- Substrate specificity of YidC
- YidC depletion affects F1F0 ATPase biogenesis
- YidC depletion affects Cyo oxidase biogenesis
- Properties of F0c and CyoA
- Membrane assembly of F0c
- Membrane assembly of CyoA
- E. coli membrane proteins biogenesis
- YidC: molecular chaperone and insertase?
- X-ray structure of SecYEG
- People and projects
- Acknowledgements
Topics Covered
- SRP-mediated targeting to the inner membrane
- Structure and function of the Sec-translocon in membrane insertion
- Role of YidC as an insertase and membrane chaperone
Talk Citation
Luirink, J. (2007, October 1). The biogenesis of E. coli inner membrane proteins [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 15, 2024, from https://doi.org/10.69645/COIS9876.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Joen Luirink has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.