Molecular ChaperonesPrinciples and Diseases

Published October 2007 25 lectures
Prof. Walid A. Houry
University of Toronto, Canada
Summary

Molecular chaperones are a fundamental group of proteins that have been identified only relatively recently. They are key components of a protein quality machinery in the cell which ensures that the folding process of any newly-synthesized polypeptide chain results in the formation of a properly folded protein and that the... read morefolded protein is maintained in an active conformation throughout its functional lifetime.

Molecular chaperones have been shown to play essential roles in cell viability under both normal and stress conditions. Chaperones can also assist in the unfolding of misfolded proteins and in disaggregating preformed protein aggregates. Chaperones are also involved in other cellular functions including protein translocation across membranes, vesicle fusion events, and protein secretion.

In recent years, tremendous advances have been made in our understanding of the biology, biochemistry, and biophysics of function of molecular chaperones. In addition, recent technical developments in the fields of proteomics and genomics allowed us to obtain a global view of chaperone interaction networks.

Finally, there is now a growing interest in the role of molecular chaperones in diseases. This series of talks aims at providing a comprehensive analysis of the structure and function of diverse systems of molecular chaperones and their role in cell stress responses and in diseases.