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Printable Handouts
Navigable Slide Index
- Introduction
- Lecture overview
- Dendritic cells in innate and adaptive immunity
- Viral defense by mucosal dendritic cells
- Inhibitors of DC-SIGN
- The C-type lectin DC-SIGN
- Common classes of mammalian glycans
- Glycosylation occurs in the ER and the Golgi
- DC-SIGN receptor for HIV1 and HCV on DC
- Does DC-SIGN present to T cells?
- HIV1 transmission to T cells by DCs
- HIV1 transmission by DC-SIGN
- DC-SIGN and HIV1 infection of T cells
- Langerhans cells in HIV transmission
- Langerhans cells
- DC-SIGN as a pathogen receptor
- Gp120 binding: carbohydrate fingerprint
- Langerin protects HIV1 transmission by LCs
- LC protects us against infection with HIV1
- Bacteria recognition by human immune system
- Pathogen-associated molecular patterns
- Toll-like receptors
- TLRs and C-type lectins
- Antigen presentation by C-type lectins
- Glycosylation
- Glycan specificity of the C-type lectins
- DC-SIGN binding pathogens
- Orchestrating adaptive immune response
- Helicobacter pylori
- Phase variation of Helicobacter pylori LPS
- DC-SIGN-mediated skewing of CD4 response
- Mycobacterium tuberculosis
- M. tuberculosis cell wall
- DC-SIGN binds mycobacterial ManLAM
- DC-SIGN enhances IL-10 responses
- Targeting DC-SIGN to modulate immune response
- C-type lectins (DC-SIGN) in bacterial infections
- Cross-talk between pathogen receptors
- C-type lectin function
- Expression and binding of Lewis antigens
- DCs interact with neutrophils through DC-SIGN
- DC-SIGN binds 160 kD ligands on neutrophils
- CEACAM1 binds DC-SIGN through Lewis
- Mac1 and CEACAM1 on other cells
- PMNs modulate DC-induced immune responses
- PMN and DC - innate to adaptive responses
- Glycan changes associated with cancer
- DC-SIGN binds cancer-associated cell lines
- CEA and CEACAM1 in colon carcinoma
- Immature DCs bind CEA from tumor colon
- CEA and CEACAM1 from colon carcinoma
- C-type lectin function (2)
- Acknowledgements
Topics Covered
- Function of Carbohydrate Recognition by C-type Lectins on Dendritic Cells in “Host Defense” and “Immune Homeostasis"
- Dendritic cells in innate and adaptive immunity
- Viral defense by mucosal dendritic cells
- Inhibitors of DC-SIGN block virus binding and cellular function
- The C-type lectin DC-SIGN
- Common classes of mammalian glycans
- DC-SIGN receptor for HIV-1 and Hepatitis C virus on DC
- Langerhans cells
- LC protects us against infection with HIV-1
- How are bacteria recognized by the human immune system?
- Pathogen-associated molecular patterns
- Toll-like receptors
- TLRs and C-type lectins
- Antigen presentation by C-type lectins
- Glycan specificity of the C-type lectins
- Orchestrating adaptive immune responses by pathogen recognition
- Helicobacter pylori
- Mycobacterium tuberculosis
- DC-SIGN enhances TLR-induced IL-10 responses
- Pathogens target DC-SIGN to modulate immune responses
- C-type lectins (DC-SIGN) in bacterial infections
- C-type lectin function
- DCs interact with neutrophils through DC-SIGN
- Glycan changes associated with cancer
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Talk Citation
Van Kooyk, Y. (2013, September 23). Function of carbohydrate recognition by C-type lectins on dendritic cells in “host defence” and “immune homeostasis” [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 21, 2024, from https://doi.org/10.69645/CRXS6433.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Yvette Van Kooyk has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Function of carbohydrate recognition by C-type lectins on dendritic cells in “host defence” and “immune homeostasis”
Published on September 23, 2013
49 min
A selection of talks on Biochemistry
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