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- Introduction
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1. Drosophila genetics - the first 25 years
- Prof. Dan Lindsley
- Establishment of the Primary Body Axes
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2. Homeotic genes in Drosophila's bithorax complex - The legacy of Ed Lewis
- Prof. Francois Karch
- Cell Type Specification and Organ Systems
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4. From germ cell specification to gonad formation
- Prof. Ruth Lehmann
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5. Drosophila stem cells
- Prof. Michael Buszczak
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6. Legacy of drosophila genetics: female germline stem cells
- Prof. Michael Buszczak
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7. Intestinal stem cell-mediated repair in Drosophila 1
- Prof. Tony Ip
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8. Intestinal stem cell-mediated repair in Drosophila 2
- Prof. Tony Ip
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10. Axon guidance in Drosophila
- Prof. John Thomas
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11. Development and physiology of the heart
- Prof. Rolf Bodmer
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12. Identification of host defenses in the Drosophila gut using genome-scale RNAi
- Prof. Dominique Ferrandon
- Genome Organization and Function
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13. The genetic analysis of meiosis in Drosophila melanogaster females
- Prof. R. Scott Hawley
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15. Dorsal-ventral patterning of the Drosophila embryo
- Prof. Mike Levine
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17. Genome-wide pooled CRISPR screen in arthropod cells
- Prof. Norbert Perrimon
- Behavior
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19. Genetics of chemosensory transduction: taste and smell
- Dr. Leslie Vosshall
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20. Cracking the case of circadian rhythms by Drosophila genetics
- Prof. Jeffrey C. Hall
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21. Sleep in Drosophila
- Dr. Ralph Greenspan
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23. Drosophila as a model for drug addiction
- Prof. Ulrike Heberlein
- Mechanism of Human Disease
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24. Cross-genomic analysis of human disease genes
- Prof. Ethan Bier
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25. Human neurodegenerative disease: insights from Drosophila genetics
- Prof. Nancy Bonini
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26. Metastasis of Drosophila tumors
- Prof. Allen Shearn
- Evolution of Adaptive Novelties
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28. The evolution of morphological novelty
- Prof. Nipam Patel
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29. The genetic architecture of complex traits: lessons from Drosophila
- Prof. Trudy Mackay
- Archived Lectures *These may not cover the latest advances in the field
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30. Using gene expression information to provide insights into patterning and differentiation
- Prof. Angelike Stathopoulos
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31. Regulation of gastrulation in Drosophila
- Prof. Dr. Maria Leptin
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32. microRNA function in stem cells
- Prof. Hannele Ruohola-Baker
Printable Handouts
Navigable Slide Index
- Introduction
- The phenotypic variation of traits
- Understanding variation of complex traits in human
- The genetic basis of variation for complex traits (1)
- Drosophila as a model organism
- Drosophila - unbiased mutagenesis screens
- Drosophila - whole genome transcript profile
- Drosophila - QTL mapping (1)
- Drosophila - QTL mapping (2)
- Drosophila- association mapping (1)
- Drosophila- association mapping (2)
- Many genes affect complex traits (1)
- Many genes affect complex traits (2)
- Functional tests: mutations in candidate genes
- QTL mapping: many genes affect behavior
- Many genes - pervasive pleiotropy
- Genes affecting locomotor behavior
- Locomotor behavior genes - pleiotropic effects
- Many genes - pervasive pleiotropy
- Pleiotropy vs. genetic correlation
- Pleiotropy and variable allelic effects (1)
- Pleiotropy and variable allelic effects (2)
- Genotype-phenotype associations at catsup
- Genotype - environment interactions
- Sex-environment-specific effects of life span QTLs
- Context dependent effects: epistasis
- Sex-specific epistatic effects
- Environment-specific epistatic effects
- Allelic variation of complex traits - molecular basis
- The future: Drosophila systems genetics
- Acknowledgment
- References
Topics Covered
- Complex traits
- Identifying multiple genes and environmental risk factors
- Nature of genetic variation affecting complex traits
- Drosophila as a model system
- P-element mutagenesis
- Whole genome transcript profiles of genetically divergent strains
- QTL mapping
- Association mapping
- Large numbers of loci
- Pleiotropic effects on multiple traits
- Sex, environment and genetic background dependent effects
Talk Citation
Mackay, T. (2018, May 31). The genetic architecture of complex traits: lessons from Drosophila [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 12, 2024, from https://doi.org/10.69645/BYTJ3906.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Trudy Mackay has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
The genetic architecture of complex traits: lessons from Drosophila
A selection of talks on Genetics & Epigenetics
Transcript
Please wait while the transcript is being prepared...
0:00
Good day, I'm Trudy MacKay,
a professor in the Department of Genetics
at North Carolina State University.
I'm interested in the genetic basis
of variation for complex traits.
In this talk I will explain
what I mean by complex traits,
why these traits are important,
the challenges involved in dissecting
the genetic underpinnings of these traits,
and how studies in the model genetic
organism Drosophila melanogaster have
advanced our knowledge in this field.
When I speak of a trait, I mean any
aspect of an organism's phenotype that
0:28
can be measured or quantified such
as height, weight, blood pressure or
behavioral responses to
an environmental or social cue.
There is great diversity, or variation
in phenotypes of these traits among
individuals, as illustrated by these
photos of different dog breeds.
Understanding what causes phenotypic
variation for these traits is important
from the perspective of plant and
animal breeding and evolution, for
genetic variation in these traits is the
substrate for adaptive evolution, and for
a response to human selection for improved
yield of domestic crop and animal species.
1:10
Understanding what causes variation for
complex traits is also important
from the standpoint of human health,
because there's considerable variation in
human populations in susceptibility to
common diseases,
such as heart disease and diabetes.
Conversely, there is also considerable
variation in health span,
ranging from disabling physical and
or/mental impairment in old age
to retaining full functional
capability even at advanced age,
as illustrated by the photos of
centenarians in the right panel.