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- Introduction
-
1. Drosophila genetics - the first 25 years
- Prof. Dan Lindsley
- Establishment of the Primary Body Axes
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2. Homeotic genes in Drosophila's bithorax complex - The legacy of Ed Lewis
- Prof. Francois Karch
- Cell Type Specification and Organ Systems
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4. From germ cell specification to gonad formation
- Prof. Ruth Lehmann
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5. Drosophila stem cells
- Prof. Michael Buszczak
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6. Legacy of drosophila genetics: female germline stem cells
- Prof. Michael Buszczak
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7. Intestinal stem cell-mediated repair in Drosophila 1
- Prof. Tony Ip
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8. Intestinal stem cell-mediated repair in Drosophila 2
- Prof. Tony Ip
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10. Axon guidance in Drosophila
- Prof. John Thomas
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11. Development and physiology of the heart
- Prof. Rolf Bodmer
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12. Identification of host defenses in the Drosophila gut using genome-scale RNAi
- Prof. Dominique Ferrandon
- Genome Organization and Function
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13. The genetic analysis of meiosis in Drosophila melanogaster females
- Prof. R. Scott Hawley
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15. Dorsal-ventral patterning of the Drosophila embryo
- Prof. Mike Levine
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17. Genome-wide pooled CRISPR screen in arthropod cells
- Prof. Norbert Perrimon
- Behavior
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19. Genetics of chemosensory transduction: taste and smell
- Dr. Leslie Vosshall
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20. Cracking the case of circadian rhythms by Drosophila genetics
- Prof. Jeffrey C. Hall
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21. Sleep in Drosophila
- Dr. Ralph Greenspan
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23. Drosophila as a model for drug addiction
- Prof. Ulrike Heberlein
- Mechanism of Human Disease
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24. Cross-genomic analysis of human disease genes
- Prof. Ethan Bier
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25. Human neurodegenerative disease: insights from Drosophila genetics
- Prof. Nancy Bonini
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26. Metastasis of Drosophila tumors
- Prof. Allen Shearn
- Evolution of Adaptive Novelties
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28. The evolution of morphological novelty
- Prof. Nipam Patel
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29. The genetic architecture of complex traits: lessons from Drosophila
- Prof. Trudy Mackay
- Archived Lectures *These may not cover the latest advances in the field
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30. Using gene expression information to provide insights into patterning and differentiation
- Prof. Angelike Stathopoulos
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31. Regulation of gastrulation in Drosophila
- Prof. Dr. Maria Leptin
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32. microRNA function in stem cells
- Prof. Hannele Ruohola-Baker
Printable Handouts
Navigable Slide Index
- Introduction
- The Drosophila heart is a simple tube
- Tinman is required for heart development
- Formation of the drosophila heart
- Is drosophila heart similar to vertebrate heart?
- Embryology of heart formation in flies & vertebrates
- Origin of Drosophila and vertebrates hearts
- Conserved heart formation
- Genetic control of heart development
- How is the heart positioned correctly?
- Wg & dpp provide information for heart positioning
- Wg & dpp over expression
- Stage 11 tinman pattern affected by wg and dpp
- Stage 12 tinman pattern affected by wg and dpp
- Pattern of dpp and wg predicts tinman expression
- Wg and dpp signaling specifies cardiac positioning
- Combinatorial specification of heart progenitors
- Neuromancer/Tbx20 is required for cell polarity
- Other genes important for heart morphogenesis
- Slit function and slit mutations
- Summary of cardiac morphogenesis
- Even-skipped expressing cells
- Regulation of mesodermal even-skipped enhancer
- Transcription factor consensus binding sites
- Eve expression within cardiac mesoderm
- Ladybird & even-skipped are mutual repressors
- Ladybird & even-skipped are mutual repressors (2)
- Eve progenitors within cardiac mesoderm
- Hedgehog effect on Eve and Lbe
- Hedgehog sets up a gradient of RTK signalling
- Combinatorial specification of heart progenitors (2)
- Further specializations towards a functioning heart
- Image-based analysis of heart function
- Image-based analysis of heart contractions
- KCNQ genes
- KCNQ as a part of the repolarization mechanism
- Rhythmicity abnormalities in KCNQ mutants
- Index of arrhythmia
- Distribution of systolic intervals
- A cardiac stress test
- Heart failure rate
- Decline of cardiac function with age
- InR pathway is a highly conserved regulator
- Aged chico mutants have low heart failure rate
- Cardiac aging not observed in chico or InR mutants
- Heart-specific over expression of InR signalling
- Insulin - TOR signalling pathways
Topics Covered
- Genetic basis of heart development, function and aging
- Genetic model (Drosophila) for heart research
- Drosophila model for congenital heart disease
- Drosophila model for arrhythmias and cardiomyopathies
- Drosophila model for age-dependent heart disease
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Bodmer, R. (2018, May 31). Development and physiology of the heart [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 8, 2024, from https://doi.org/10.69645/ROKH9492.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Rolf Bodmer has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Cardiovascular & Metabolic
Transcript
Please wait while the transcript is being prepared...
0:00
It's a pleasure for me to talk about the
"Development and Physiology of the Heart"
as part of the "Legacy of
Drosophila Genetics", Henry Stewart Talks.
My name is Rolf Bodmer.
0:13
The Drosophila heart during
embryogenesis starts out as
a simple tube as indicated here.
In the top panel you see the inner
blue myocardial cells and
the outer brown pericardial cells.
And the diagram below illustrates that
there's really only two layers of cells,
two rows of cells that come together and
form a lumen as indicated in
the bottom portion of that diagram.
0:42
Now over 15 years ago,
we started embarking in a search for
genes that are required for
heart formation in Drosophila,
because we thought we could learn
a lot from this organism in terms of
genetic determinants that are necessary
for the development of the heart,
sort of as a prototype for
any organism that had a heart.
The first mutant that we had identified,
we called tinman,
because in tinman mutants,
the heart does not form.
So in wild-type, you have a normal
heart being formed, in tinman mutants,
the heart does not form.
In addition, tinman is expressed
at these late stages of
embryogenesis exclusively in the heart.
1:25
To understand how
the Drosophila heart forms,
I would like to review some aspects
of gastrulation that will be
illustrative of how the heart
formation comes about embryologically.
So in the Drosophila blastoderm stage,
you can see that helix-loop-helix
transcription factor twist marks
the mesoderm which then invaginates and
migrates along the ectoderm
to the dorsal edge.
So it forms a sort of a monolayer.
And you can see the illustration of this
in a diagram that you have this
model here of mesodermal cells, and
the most dorsal cells marked in red
are then the cardiac progenitor cells.
And it's these cells that are in
the bottom right in situ panel of
RNA expression in stage 12 embryo marks
exclusively the heart progenitor cells.
Tinman is actually expressed all
through the mesoderm early on and
then becomes restricted to dorsal
mesoderm and only towards the middle and
end of embryogenesis is it marking
exclusively the cardiac progenitor cells.