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- Introduction
-
1. Drosophila genetics - the first 25 years
- Prof. Dan Lindsley
- Establishment of the Primary Body Axes
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2. Homeotic genes in Drosophila's bithorax complex - The legacy of Ed Lewis
- Prof. Francois Karch
- Cell Type Specification and Organ Systems
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4. From germ cell specification to gonad formation
- Prof. Ruth Lehmann
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5. Drosophila stem cells
- Prof. Michael Buszczak
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6. Legacy of drosophila genetics: female germline stem cells
- Prof. Michael Buszczak
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7. Intestinal stem cell-mediated repair in Drosophila 1
- Prof. Tony Ip
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8. Intestinal stem cell-mediated repair in Drosophila 2
- Prof. Tony Ip
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10. Axon guidance in Drosophila
- Prof. John Thomas
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11. Development and physiology of the heart
- Prof. Rolf Bodmer
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12. Identification of host defenses in the Drosophila gut using genome-scale RNAi
- Prof. Dominique Ferrandon
- Genome Organization and Function
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13. The genetic analysis of meiosis in Drosophila melanogaster females
- Prof. R. Scott Hawley
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15. Dorsal-ventral patterning of the Drosophila embryo
- Prof. Mike Levine
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17. Genome-wide pooled CRISPR screen in arthropod cells
- Prof. Norbert Perrimon
- Behavior
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19. Genetics of chemosensory transduction: taste and smell
- Dr. Leslie Vosshall
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20. Cracking the case of circadian rhythms by Drosophila genetics
- Prof. Jeffrey C. Hall
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21. Sleep in Drosophila
- Dr. Ralph Greenspan
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23. Drosophila as a model for drug addiction
- Prof. Ulrike Heberlein
- Mechanism of Human Disease
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24. Cross-genomic analysis of human disease genes
- Prof. Ethan Bier
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25. Human neurodegenerative disease: insights from Drosophila genetics
- Prof. Nancy Bonini
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26. Metastasis of Drosophila tumors
- Prof. Allen Shearn
- Evolution of Adaptive Novelties
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28. The evolution of morphological novelty
- Prof. Nipam Patel
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29. The genetic architecture of complex traits: lessons from Drosophila
- Prof. Trudy Mackay
- Archived Lectures *These may not cover the latest advances in the field
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30. Using gene expression information to provide insights into patterning and differentiation
- Prof. Angelike Stathopoulos
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31. Regulation of gastrulation in Drosophila
- Prof. Dr. Maria Leptin
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32. microRNA function in stem cells
- Prof. Hannele Ruohola-Baker
Printable Handouts
Navigable Slide Index
- Introduction
- Introducing the fly
- Fly body structure
- The fly's head
- Dorsal thorax of the fly
- The fly's wings
- The fly's abdomen
- The fly's karyotype
- The birth of Drosophila genetics
- Sex-limited Inheritance in Drosophila
- Discovering other sex-limited mutations
- The coupling phenomenon
- Coupling measures distance on the chromosome
- Interpretation of cross-over data
- Chromosome II - second linkage group
- Discovery of the third and forth linkage groups
- Transmission of linkage groups
- Illustration of Bridges experiment
- Cross-over takes place in the 4-strand stage
- Cross with Y chromosome (1)
- Cross with Y chromosome (2)
- Oogonial metaphases results
- Primary and secondary nondisjunction
- Researchers in the history of Drosophila study
- Leading researchers in Drosophila study
- Bridges further research
- Intersexes in Drosophila
- Chromosome aberrations
- A.H. Sturtevant
- H.J. Muller studied the gene
- Muller discovery of the mutagenic effect of X-rays
- H.J. Muller
- Cross measuring X-rays effect
- Examining visible mutations
- Studying X-chromosome fragments
- X-chromosome study results
- Cytological approach to Drosophila research
- Images of male and female chromosomes
- Usage of polytene chromosomes in research
- Only U-chromatic arms polytenized
- Inversion between homologue chromosomes
- polytene map correlation with metaphase map
- Modern day polytene squash
- Organization of the polytene genome
- Polytene X-chromosome map
- C.B. Bridges
Topics Covered
- Sex linked inheritance, linkage and linear chromosome maps
- Non-disjunction
- Genic balance theory of sex determination
- Chromosome aberrations
- Mutational studies of the gene
- X-ray induction of gene and chromosome mutations
- Cytological dissection of the X chromosome
- Mitotic cytology
- Polytene cytology
Talk Citation
Lindsley, D. (2018, May 31). Drosophila genetics - the first 25 years [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 12, 2024, from https://doi.org/10.69645/FGAV1390.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Dan Lindsley has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Genetics & Epigenetics
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, my name is Dan Lindsley,
and this is the introductory
lecture to this series on
Drosophila genetics and biology.
I'm going to try to summarize the results
of the first 25 years of work on
Drosophila genetics, but before I do that
I would like to introduce you to the fly.
0:22
As you can see from this slide,
the fly is a small organism, but
one pair in a confined space can produce
50 to 100 progeny in two weeks' time.
0:34
This slide shows two pictures
of adult flies, the upper one is
a dorsal view of a male and
the lower one a lateral view of a female.
These are typical insects,
they have three body parts, the head,
the thorax, and the abdomen.
The thorax contains three pairs of legs,
and in most insects two pairs of wings,
but in the Diptera the posterior
pair of wings is replaced by a small
mechano-sensory organ known as
the haltere or the balancer.
The male's wings are spread to provide
a good view of the of the veination
which is a constant feature of
the wings and subject to mutation.
I now want to proceed to discuss
the body parts one at a time.
1:22
First being the head, the upper left-hand
picture is the head of a wild-type fly,
a major feature of the head is
the large red compound eye,
it's composed of some 800 unit eyes or
ommatidia, which are arranged
in a hexagonal array.
Anterior to the eye are the antennae,
and below are the mouth parts,
the head also contains
a specific set of bristles.
Eye mutations involve several features
of the eye, eye color as shown
in the white mutant, or eye texture
as shown in the rough-eye mutant
where the arrangement of the ommatidia
becomes completely destroyed.
In the bottom row are three
eye mutants which affect
both size, shape, and texture of the eye.