An introduction to genetic association analysis

Published on April 19, 2016   39 min

Other Talks in the Series: Statistical Genetics

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I'm Jenny Barrett, Professor of Statistical Genetics at the University of Leeds in the UK. And in this talk, I'm going to give An Introduction to Genetic Association Analysis.
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Genetic association simply refers to the statistical association between the genetic variant and the trait. The trait could be categorical, such as whether or not someone has diabetes or continuous, like height. So for a disease trait, genetic association is seen if the disease frequency varies according to genotype, or equivalently, if particular genotypes are more common in disease cases than in controls from the same population. Here, if we look at the three genotypes AA, AG, GG, defined by one particular A-G single nucleotide polymorphism or SNP, we see the frequency of a common disease in people with the three genotypes varies from 515 per 10,000 adults in those with the AA genotype to 712 per 10,000 adults with the GG genotype. Similarly, for a quantitative trait, we might see a slightly different distribution of trait values according to genotype illustrated here by height in adult males where we can see the mean height is highest in those with the AA genotype.
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An introduction to genetic association analysis

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