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Printable Handouts
Navigable Slide Index
- Introduction
- Scleroderma
- Systemic sclerosis - epidemiology
- Systemic sclerosis - tissue pathologies
- Clinical manifestations of scleroderma
- Scleroderma - pathology
- SSc - vasculopathy and fibrosis
- Arterial fibrosis - pathology
- SSc nailford capillary abnormalities
- Evidence of genetic effects
- Twin concordance
- Prevalences in american indians
- Choctaw nation of Oklahoma - location
- Geneaology of SSc in the Choctaw
- Pushmataha
- Fibrillin - 1 gene (fbn1)
- Genome scan for disease loci associated with SSC
- Allelic distribution - cases and controls
- Autoimmunity regions from genome scans
- Autoimmunity genes
- Gene mapping in scleroderma
- MHC class 2 haplotypes
- Protein tyrosine phosphatase 2 (PTPN22)
- PTPN22 in scleroderma
- Genetic associations in scleroderma
- Uses for DNA microarrays
- SSC - twin concordance
- SSC fibroblast DNA microarrays
- Microarray analyses
- Dendrogram for clustering experiments
- Genes clustered in SSc affected individuals
- Twin concordance - fibroblast genes
- Fibroblast microarray results imply genetic effect
- SSc twin sera stimulate normal fibroblasts
- SSc - occurrence and risk in families
- Uses for DNA microarrays
- Expression of SPARC gene
- Increased SPARC expression in SSc fibroblasts
- SPARC stain in fibroblasts after SPARC siRNA
- Western blots of collagen type l and SPARC
- Uses for DNA microarrays
- Dendrogram for clustering experiments - blood cells
- Microarrays of peripheral blood cells
- Dendrogram for clustering experiments
- Genes clustered in affected individuals
- Interferon- related genes
- Vasculotrophic genes
- Immune function genes
- On-line data sources
- Acknowledgements
- Support
Topics Covered
- The genetics of scleroderma
- What is the evidence that it is genetic?
- Familial aggregation and twin studies
- The use of large case-control studies to identify the genes
- The emerging genetic heterogeneity of the disease
- The use of genomic approaches to discover the molecular pathways contributing to this disease
- Using microarrays to better understand pathogenesis and to define prognosis
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Talk Citation
Arnett, F. (2007, October 1). Indians, twins and scleroderma: genetic and genomic studies [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 8, 2024, from https://doi.org/10.69645/EFKW9262.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Frank Arnett has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.