• Statistical Genetics of Complex Diseases
• 38 min
  1. Population genetics considerations

  • Prof. Nan Laird
• 39 min
  2. Gene-by-environment interaction: study designs and analytical methods

  • Prof. L. Adrienne Cupples
• 59 min
  3. Analysis of SNP haplotypes

  • Prof. Lyle Palmer
• 36 min
  4. Statistical issues in epidemiological studies of gene-environment interaction

  • Dr. Peter Kraft
  • Prof. Donna Spiegelman
• Molecular Epidemiology of Pulmonary Diseases
• 57 min
  5. Molecular epidemiology of lung cancer

  • Prof. David Christiani
• 34 min
  6. Ethical issues in molecular epidemiology and studies of gene-environment interactions

  • Dr. Richard Sharp
• Autoimmune Diffuse Connective Tissue Diseases
• 29 min
  7. Environmental scleroderma: the evidence for putative triggers

  • Prof. Maureen Mayes
• Drug-Induced Disease
• 35 min
  8. Drug-induced lupus

  • Prof. Evelyn Hess
• Archived Lectures *These may not cover the latest advances in the field
• 41 min
  9. Biomarkers of exposure

  • Prof. Thomas Smith
• 43 min
  10. GIS and spatial statistics

  • Prof. Louise Ryan
• 47 min
  11. Gene-by-environment interactions in COPD

  • Prof. Edwin Silverman
• 40 min
  12. Occupational and environmental influences on the development and course of lupus

  • Dr. Glinda Cooper
• 54 min
  13. Genetic susceptibility in granulomatous disorders: chronic beryllium disease and sarcoidosis

  • Prof. Lee Newman
• 29 min
  14. Indians, twins and scleroderma: genetic and genomic studies

  • Prof. Frank Arnett
• 27 min
  15. Gene by environment interaction in asthma

  • Prof. Scott Weiss
• 42 min
  16. Molecular epidemiology of lung cancer

  • Prof. David Christiani
• 18 min
  17. Racial and ethnic variation in systemic lupus erythematosus and systemic sclerosis (scleroderma)

  • Dr. Patricia Fraser
• 47 min
  18. Infectious environmental factors and systemic lupus erythematosus

  • Prof. Judith James

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Environmental epidemiology
3. Measuring exposure
4. What is GIS?
5. Types of geo-referenced data
6. Using GIS to define exposure
7. Area-based exposure
8. Using area-based exposure measures
9. Example-social disadvantage and heart diseas
10. Modeling area-based data
11. IHD rates by age and gender
12. Effects of social diadvantage
13. Some technical details
14. Sensitivity to moddling method
15. Some final remarks about area-based analysis
16. Distance-based exposure
17. Childhood cancer and petrochmical plants
18. Example-constructing an exposure surface
19. Closer look at the exposure surface
20. Other uses of GIS in environmental epidemiology
21. Example-lung cancer in proximity to military base
22. Raw data can be hard to interpret
23. Spatial smoothing
24. Example-geographical variation in allergic reponse
25. More on geoadditive modeling
26. Searching for clusters
27. Conclutions

Topics Covered

• Introduction to GIS and its role in environmental epidemiology
• Ways that GIS can be used to quantify environmental exposures
• Statistical methods for analyzing spatial data
• Examples where GIS has played a useful role

Links

Series:

• Gene-Environment Interactions

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on October 17, 2015

Financial Disclosures

• Prof. Louise Ryan has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.