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- Introduction to Free Radicals and Oxidative Stress
- Chemistry, Biochemistry and Cell Biology
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2. Peroxynitrite biochemistry oxidation and nitration reactions
- Prof. Rafael Radi
- Oxidative Damage to Cellular Constituents
- Cellular Protection Against Oxidative Stress
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4. The SODs
- Prof. Daret St. Clair
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5. Glutathione: antioxidant defense and regulation of its synthesis
- Prof. Henry Jay Forman
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6. Vitamin E and the metabolic syndrome
- Prof. Maret Traber
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7. Cell signaling by vitamin E
- Prof. Angelo Azzi
- Fertility, Growth, Development, Aging and Free Radicals
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8. Selenium and male fertility
- Prof. Matilde Maiorino
- Free Radicals and Disease
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9. Oxidative stress and disease: atherosclerosis
- Prof. Giuseppe Poli
- Archived Lectures *These may not cover the latest advances in the field
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11. The chemistry and biochemistry of partially reduced oxygen species
- Dr. Willem Koppenol
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12. Chemistry and biochemistry of molecular probes used in the detection of reactive oxygen and nitrogen species
- Prof. Balaraman Kalyanaraman
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13. Generation of reactive oxygen species by mitochondria
- Dr. Enrique Cadenas
- Dr. Derick Han
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14. Exercise and free radical generation by contracting skeletal muscle
- Prof. Malcolm Jackson
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15. Lipid peroxidation: from basic mechanisms to clinical relevance
- Prof. Jason Morrow
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16. Protein oxidation and removal of oxidized proteins by proteolysis
- Prof. Tilman Grune
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17. Oxidative stress in aging
- Dr. Jose Vina
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18. Oxidative stress in disease: cardiac ischemia/reperfusion injury
- Prof. Jay Zweier
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19. How trypanosomes cope with oxidative stress
- Prof. Leopold Flohe
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20. Oxidative stress in ALS
- Prof. Dame Pamela Shaw
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21. Antioxidants and immune response and infectious diseases
- Prof. Simin Meydani
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22. Oxidative stress in development and neonatal diseases
- Dr. Phyllis Dennery
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24. Oxidative DNA damage: mechanisms, repair and disease
- Prof. Miral Dizdaroglu
Printable Handouts
Navigable Slide Index
- Introduction
- Anterior wall myocardial infraction
- Establish early reperfusion
- Reperfusion injury
- Mechanisms of reperfusion injury
- Oxygen radicals are central mediators of injury
- Free radicals in biology
- Evidence for the role of oxygen radicals in injury
- Pressure recovery after ischemia and reperfusion
- Treatment with hSOD in vivo
- Electron paramagnetic/spin resonance
- 5,5-dimethyl-1-pyrroline N-oxide (DMPO)
- EPR spin trapping experiment
- Ischemic duration with maximum radical formation
- Radical generation depends on ischemic duration
- Treatment with active and inactive SOD
- SOD1 over-expression prevents reperfusion injury
- Reoxygenated endothelial cells generate radicals
- Xanthine oxidase - a source of radical generation
- XO and XDH are present in the heart
- XO substrates are formed during ischemia
- EPR spin trapping of endothelial cells and hearts
- Superoxide and functional adhesion
- Superoxide affects adhesion molecule expression
- Superoxide activates leukocyte adhesion
- Role of neutrophils and plasma factors in injury
- Leukocytes and complement enhance injury
- Leukocytes, complement and radical generation
- Leukocytes, complement and injury - conclusions
- Cellular mechanisms of radical generation
- Important biological radicals
- The reaction catalyzed by NO synthase (NOS)
- NOS activity in L-arginine-depleted cells
- N-methyl-D-glucamine dithiocarbamate (MGD)
- EPR spectra of nitric oxide in MGD labeled hearts
- Time course of NO generation during ischemia
- NO generation in the ischemic heart
- Imaging of nitric oxide in the rat heart
- NO-heme complexes formation in ischemic heart
- Myocardial salvage in acute myocardial infarction
- How can we translate this to the clinic?
- Low molecular weight SOD-mimetic (M40403)
- Methods
- Progression of infarct size over time
- Adjusted mean values for infract size
- SOD-mimetic (M40403) study - conclusions
- EPR imaging system setup
- EPR imaging
- EPR imaging of oxygen
- EPR imaging of redox state
- Conclusions
- Acknowledgments
- The OSU heart center
Topics Covered
- Reperfusion injury
- Oxygen radicals are mediators of injury
- Reperfusion radical generation and duration of ischemia
- SOD1 and reperfusion
- Xanthine oxidase as a source of radical generation
- Xanthine oxidase substrates are formed during ischemia
- Superoxide and adhesion molecule expression
- Post-ischemic injury and leukocytes
- NO generation during ischemia
- NO-heme complexes in ischemic heart
- Maximizing myocardial salvage
- EPR imaging
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Talk Citation
Zweier, J. (2007, November 1). Oxidative stress in disease: cardiac ischemia/reperfusion injury [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 26, 2024, from https://hstalks.com/bs/777/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Jay Zweier has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.