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Expression vs. function of ABC transporters at the blood-brain barrier

Published on February 3, 2019   42 min

A selection of talks on Biochemistry

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0:00
"Expression versus Function of ABC Transporters at the Blood-Brain Barrier". I am Jean-Michel Scherrmann, I am professor of Pharmacokinetics at the Faculty of Pharmacie of Paris Descartes University.
0:14
During my presentation, I will give some general properties on the ABC transporters and on the blood-brain barrier. I will describe P-glycoprotein or ABCB1, BCRP, or ABCG2, and the multi-drug resistant proteins, the MRPs at the level of the blood-brain barrier. In the last part, I will report our data on the gene and protein expression of this ABC in the human brain microvessels. And finally, I will conclude my presentation by the impact that these ABC transporters in the blood-brain barrier can have, in the research and development of central nervous system drugs.
1:01
The ABC transporters belong to a superfamily with 48 reported genes in humans. Four subfamilies, A, B, C, and G contain several isoforms, which are implied in drug transport. The most known is a full transporters ABCB1 or P-glycoprotein, which is mostly expressed in the plasma membrane, but also in some sub-cellular sites, like other ABC proteins. This raises the question of the ABC transporter role in the intracellular drug disposition. Nevertheless, the subfamily D, E, and F do not seem involved in the transport and expressed at the level of the blood-brain barrier.

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Expression vs. function of ABC transporters at the blood-brain barrier

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