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Printable Handouts
Navigable Slide Index
- Introduction
- What are virulence plasmids?
- Why are they important?
- Types of virulence plasmids
- Virulence plasmids
- Toxin plasmids
- Metabolic plasmids
- Adhesin plasmids
- Other virulence plasmids
- The anthrax toxin plasmids
- Genetic organisation of pXO1
- Role of pXO1 in virulence
- Interaction with host cells
- Genetic organisation of pXO2
- Regulation of toxin genes
- Clostridial toxin plasmids: Clostridium tetani
- Clostridial toxin plasmids: Clostridium perfringens
- The CPE plasmids
- Conjugation locus of C. perfringens toxin plasmids
- Metabolic plasmids to be discussed
- Mycolactone biosynthesis and pMUM001
- pMUM001: a blueprint for mycolactone synthesis
- mls genes are modular
- The pJM1 virulence plasmid of Vibrio anguillarum
- Genetic map of pJM1
- Adhesin plasmids to be discussed
- Enterotoxigenic E. coli infections
- Enteropathogenic E. coli infections
- Genetic map of pB171
- Linear virulence plasmids of Borrelia
- DNA molecules of B. burgdorferi
- Other virulence plasmids to be discussed
- Shigella
- Shigella invasion process
- The entry region on Shigella virulence plasmids
- Mode of action of T3SS
- The Ipa proteins
- Role of IpaA-C in Shigella entry
- Other T3SS effectors
- Other proteins encoded by virulence plasmid
- Yersinia
- Yop plasmids
- Summary
- Acknowledgements
Topics Covered
- Definition and importance of virulence plasmids
- Types of virulence plasmids
- Toxin plasmids
- The anthrax toxin plasmids
- Clostridial toxin plasmids
- Metabolic plasmids
- Mycolactone biosynthesis by Mycobacterium ulcerans
- Iron uptake by Vibrio anguillarum
- Adhesin plasmids
- Enterotoxigenic E. coli: CFA
- Enteropathogenic E. coli: BFP
- Linear plasmids of Borrelia
- Other virulence plasmids
- Shigella: type III secretion system, ipa genes
- Yersinia: type III secretion system, yop genes
- Bacillus anthracis is the causative agent of anthrax
- pXO1 encodes toxin and regulatory genes
- pXO2 encodes capsule and regulatory genes
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Talk Citation
Rood, J. (2008, January 28). Virulence plasmids [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 11, 2024, from https://doi.org/10.69645/GBPR3227.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Julian Rood has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.