Registration for a live webinar on 'Neuroleptic malignant syndrome' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Preface
- Terminology
- Mechanism of action of PSK systems
- Types of PSK
- Typical proteic PSK
- The Ccd system of plasmid F
- The CcdA protein
- CcdA-CcdB binding to DNA
- Toxin-antitoxin structure
- CcdB target: gyrase
- GyrA binding of CcdB
- Toxin-antitoxin families
- Alternative arrangements of PSK systems
- Modular organization of antitoxins
- Chromosomally encoded proteic TA systems
- Antisense-RNA regulated PSK loci
- The problem with antisense RNA systems
- The R1-encoded hok/sok locus
- hok/sok solution to toxin mRNA persistence
- Target of the Hok toxin: ghost cell formation
- The pAD1 par locus
- RNA I and RNA II secondary structures
- Mechanism of RNA I-RNA II interaction
- The RNA I-RNA II complex is unusually stable
- Fst effects on chromosome segregation
- Fst effects on cell division
- Final note of caution
- Review (general)
- Review (proteic systems)
- Review (antisense RNA regulated systems)
Topics Covered
- Introduction to post-segregational killing systems
- Proteic post-segregational killing systems
- The Ccd system
- Other proteic systems
- Antisense RNA-regulated post-segregational killing systems
- The plasmid R1 hok/sok system
- The plasmid pAD1 par system
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Weaver, K. (2008, January 28). Plasmid stabilization by cell killing [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 8, 2024, from https://doi.org/10.69645/UVBC6707.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Keith Weaver has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.