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Printable Handouts
Navigable Slide Index
- Introduction
- Plasmid partition and chromosome dynamics
- Plasmid stability systems
- Why do plasmids need partition systems?
- Plasmid localization in the cell cycle
- Plasmid partition cassettes
- Classes of partition systems
- Type 1: walker ATPases
- Plasmid partition sites (1)
- Plasmid partition sites (2)
- Repressor and corepressors
- The diversity of plasmids with type 1 par systems
- Type 2: actin ATPases
- Plasmids with multiple par systems
- Mechanistic questions
- The action of ParA and ParB proteins: ParB
- The P1 partition complex
- Visualization of partition complexes
- ParB structure and function
- The structure of a partition complex
- ParBs of Type 1 par systems
- Small ParBs are RHH2 dimers
- Omega RHH2 binds DNA
- The action of ParA and ParB proteins: ParA
- Plasmid localization requires ParA
- Measurements of localization
- Walker-type partition ATPases
- ParA binds and hydrolyzes ATP
- ParA is a transcriptional repressor
- ParA has site-specific DNA binding activity
- Mutations in ParA reveal ATP interactions
- The ATP-ADP switch
- How does ParA mediate plasmid localization?
- ParM and actin share properties
- ParM filaments drive plasmids apart
- ParM polymerization drives R1 partition
- Do walker-type ATPases polymerize?
- Partition ATPase dynamics: observations
- Model: par complex dynamics
- Remaining questions
Topics Covered
- Mechanisms of plasmid segregation and partition reactions
- Types of plasmid partition systems in bacteria
- ParA partition ATPases
- Structural biology of partition-site binding proteins
- Chromosome dynamics
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Talk Citation
Funnell, B. (2008, January 28). Plasmid segregation and stability in bacteria [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 4, 2024, from https://doi.org/10.69645/ZFPH4100.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.