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1. Glucuronidation and UGT
2. Content of presentation
3. The glucuronidation reaction
4. UDP-glucuronic acid
5. Glucuronidation reaction scheme
6. Glucuronidation - detox. mechanism
7. UGT substrates - aliphatic alcohols
8. UGT substrates - phenols
9. UGT substrates - carboxylic acids
10. UGT substrates - amines
11. UGT substrates - thiols and AC
12. Sites for glucuronidation
13. Compounds eliminated by glucur.
14. Human UGTs
15. Substrate selectivity of human UGTs
16. UGT1A pharmacophores
17. UGT isoform expression
18. UGT isoform selectivity of bilirubin
19. UGT isoform selectivity of testos.
20. UGT isoform selectivity of trifluop.
21. UGT isoform selectivity of AZT
22. UGT substrate selectivity
23. UGT gene family
24. UGT1 family
25. UGT2 family
26. Topology model and dimerization
27. UGT domains
28. Topology model
29. Dimerization of UGT
30. Dimerization of UGT - implications
31. UGT gene expression
32. Tissue-specific expression of UGTs
33. UGT gene expression
34. Hepatic UGT2B gene transcription
35. UGT2B proximal promoters
36. UGT1A7-10 gene transcription
37. UGT structure-function relationship
38. The human UGT1A gene locus
39. UGT2B2/UGT2B3 hybrid proteins
40. Binding domain of UGT2B15
41. Structural domains of UGT
42. UGT genetic polymorphism
43. Disorders of bilirubin glucuronidation
44. UGT1A1 polymorphism
45. UGT1A1 - TA repeat number
46. Effect of UGT1A1*6 (G71R)
47. UGT1A1 allele frequencies
48. Influence of UGT2B15 genotype
49. UGTs and adverse events
50. Kinetics of xenobiotic glucur. in vitro
51. Bisubstrate kinetics
52. UGT kinetics - empirical models
53. Zidovudine glucuronidation
54. 4-methylumbelliferone glucur.
55. "Two site" kinetic model
56. 4-methylumbelliferone glucur.
57. UGT inhibition and drug interactions
58. Effect of fluconazole on UGT
59. Hecogenin - inhibitor of UGT1A4
60. Human hepatic UGT isoforms
61. Inhibition of human UGTs
62. Drug interactions
63. UGT reviews
64. Contact

Topics Covered

• The glucuronidation reaction
• UGT enzyme superfamily
• Importance for xenobiotic and drug metabolism
• Substrate and inhibitor specificities
• Gene regulation
• Tissue specific expression
• Genetic polymorphism
• Structure/function relationships
• Kinetic considerations

Links

Series:

• Drug Metabolizing Enzymes

Categories:

• Biochemistry
• Metabolism & Nutrition
• Pharmaceutical Sciences

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Mackenzie, P. and Miners, J. (2007, October 1). Glucuronidation and the UDP - glucuronosyltransferases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/MFGX4670.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Archived on February 9, 2016

Financial Disclosures

• Prof. Peter Mackenzie has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
• Prof. John Miners has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.