Cytochrome P450 1 Family: the roles of 1A1, 1A2 and 1B1 in drug metabolism

Published on October 1, 2007 Updated on July 31, 2016   45 min

Other Talks in the Series: Drug Metabolizing Enzymes

0:00
FRED GUENGERICH: Hello, my name is Dr. Fred Guengerich. I'm at Vanderbilt University in Nashville, Tennessee in the United States. And today I'd like to talk to you about cytochrome P450, specifically the cytochrome P450 1 family and the roles of cytochromes P450 1A1, 1A2, and 1B1 in the metabolism of drugs and other things.
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So what I'd like to do today is talk about first of all some background on cytochrome P450. Most of my slides will use the abbreviation, P450. Some may use the CYP, which is an acronym for cytochrome P450. And I also talk about the relevance to human health. I am going to give you some background on the P450 family 1 and some important concepts from the literature; particularly in terms of localization and the three-dimensional structures of these enzymes and their relevance to a function. I'm going to talk about more research on these particular P450s, the roles of family 1 P450s in the metabolism of carcinogens. I'll talk about induction and inhibition, the significance of genetic variations, and also a little bit about heterocyclic amines and the possible risk from cancer.
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Cytochrome P450 1 Family: the roles of 1A1, 1A2 and 1B1 in drug metabolism

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