Introduction to drug metabolism enzymes

Published on October 1, 2007 Reviewed on April 20, 2016   47 min

Other Talks in the Series: Drug Metabolizing Enzymes

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This talk is an introduction to the enzymes of drug metabolism. It will be illustrated by using examples from pharmaceuticals. These examples are equally applicable to other xenobiotics.
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A basic concept we need to understand with enzymes is the principle of hydrophobicity and lipophilicity. Hydrophobicity is the association of non-polar groups or molecules in an aqueous environment. It arises from the tendency of water to exclude non-polar molecules. Lipophilicity is the affinity a molecule for a lipophilic environment. We measure this in a biphasic system by determining the partition coefficient between an aqueous buffer and a lipophilic phase, such as octanol.
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Introduction to drug metabolism enzymes

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