Introduction to drug metabolism enzymes

Published on October 1, 2007 Reviewed on April 20, 2016   47 min

Other Talks in the Series: Drug Metabolizing Enzymes

This talk is an introduction to the enzymes of drug metabolism. It will be illustrated by using examples from pharmaceuticals. These examples are equally applicable to other xenobiotics.
A basic concept we need to understand with enzymes is the principle of hydrophobicity and lipophilicity. Hydrophobicity is the association of non-polar groups or molecules in an aqueous environment. It arises from the tendency of water to exclude non-polar molecules. Lipophilicity is the affinity a molecule for a lipophilic environment. We measure this in a biphasic system by determining the partition coefficient between an aqueous buffer and a lipophilic phase, such as octanol.