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As series editor, I would like to introduce you
to this series of talks.
These talks are aimed at
a wide audience interested
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in drug metabolism, and
are particularly concerned
with human drug metabolism.
This series aims to provide
an introduction to the field,
as well as information
at research level.
The first section is
concerned with general factors
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affecting drug metabolism, and
starts with an introductory talk
by Dennis Smith,
who's based at Pfizer.
We then follow with
five general talks,
including an overview on the nuclear
receptor superfamilies by Patrick
Maurel, talks on
physiological factors
and disease by Edward
Morgan and Robert Branch,
a talk on practical
approaches by Charles Crespi,
and a discussion of in silico
approaches by Maurice Dickins.
The next section is concerned
with phase I metabolism.
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In phase I metabolism, cytochromes
P450 are the best studied and most
important enzyme family,
and most of this action
is taken up with discussion
of these enzymes.
We start with two talks on
structure and reaction of P450s
from Eric Johnson
and Gordon Roberts.
We then have talks on
individual isoforms.
Fred Guengerich considers the CYP1
family, I consider the CYP2 family,
and Erin Schuetz considers CYP3A.
There is an overview of the
pharmacogenetics of cytochrome P450
from Magnus Ingelman-Sundberg.
We then turn to non-P450
metabolism, and have a talk
on oxidative metabolism from
Christine Beedham and a talk
on esterases from Clement Furlong.
Section C is concerned with
phase II drug metabolism,
