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Hello, my name is Tom Kerppola.
I am a Howard Hughes Medical
Institute investigator
and professor of
biological chemistry
at the University of
Michigan Medical School.
In my presentation I will discuss
transcription factor interactions.
I will especially focus on new
methods developed in my laboratory
for the visualization of protein
interactions in living cells.
Since I will not have time
to discuss all details
in my presentation, I have
included a link to our website.
And I invite you to
go to the website
to look for additional information.
0:36
I will start my discussion
by introducing the importance
of studies of protein
interactions for understanding
of biological
regulatory specificity.
All cells are constantly responding
to stimuli from their environments.
The specificity of these
responses is determined by protein
interactions at many
different levels.
Extracellular stimuli induce
interactions between proteins
at the membrane, including
receptors and other proteins.
These interactions produce signals that
induce additional interactions among intercellular
signal transduction proteins.
The signal transduction network
induces transcription factor
interactions, both off
DNA and upon assembly
at specific regulatory elements.
These interactions in
turn produce changes
in the expression of
specific target genes.
Thus, cells respond
to their environment
by altering protein interactions.
