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Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- Methemoglobin
- Normal oxygen transport
- Methemoglobinemia: two pronged attack
- Hb O2-saturation curve
- Methemoglobinemia and cyanosis
- Methemoglobin reduction (1)
- Methemoglobinemia
- Causes of methemoglobinemia
- NADH cytochrome b5 reductase
- CytB5R gene - structure
- Cytb5R deficiency (RCM) type I
- Cytb5R deficiency type II
- RCM type I versus type II
- Indian mutation codon 217 - Leu to Pro (L217P)
- Crystal structure of wt cytb5R and L217P mutation
- Crystal structures - effect of heat
- Cytb5R amino acid sequence
- Reported mutations of B5R gene
- Red cell enzymopathies
- Cytb5R deficiency
- Differential diagnosis of methemoglobinemia
- Methemoglobin reduction (2)
- Methemoglobinemia therapy (1)
- Methemoglobinemia therapy (2)
- Thank you
Topics Covered
- Formation of methemoglobinemia
- Review of methemoglobinemias types
- Cytochrome b5 reductase (Cytb5 R)
- Mutations and clinical phenotypes of Cytb5 R deficiency
- Differential diagnosis from other methemoglobinemias
- Therapy of methemoglobinemia
Links
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Talk Citation
Prchal, J. (2007, October 1). Cytochrome b5 reductase deficiency and hereditary methemoglobinemia [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/ZBJE7397.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Josef Prchal has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.