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Introduction to FXIII

Published on January 30, 2025   22 min

A selection of talks on Haematology

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0:00
Hello, and welcome. I'm Snejana Krassova, a medical doctor, immunohematologist, by training and former Vice President and Head of Medical Affairs at Bayer. Today, I'm very happy to introduce you to factor XIII overview and congenital factor XIII deficiency, which represents quite a problem for the diagnosis and management of the disease due to its rarity.
0:36
We're introducing factor XIII. It's a transglutaminase that catalyzes cross-linking between glutamine and lysine residues. It's a stabilizing molecule that forms the last stages of clot formation, and it's a protein involved in fibrin clot stabilization. It has numerous substrates involved in thrombosis, and it has a role in wound healing, according to the latest data.
1:06
Factor XIII activation. When thrombin cleaves off the activation peptides from the A_2B_2 tetramer in the presence of calcium and fibrin, B subunits dissociate from A subunits of the factor XIII molecule, and it leads to conformational change. That is, the activation of factor XIII, creating an activated form of factor XIII. This activated form would catalyze and cross-link fibrin, or other target proteins, and create a firm and stable clot. This is the goal.

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