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Printable Handouts
Navigable Slide Index
- Introduction
- Basic questions: randomization
- Basic questions: restricted randomization
- Possible randomization obstacles
- Predictability-reducing methods
- Covariate-adaptive methods
- Response-adaptive methods
- The need to reduce predictability
- Considering randomization in 2-dimensional space
- Efron-type biased coins
- Efron-type biased coin randomization
- Adaptive biased coins as draws from an urn
- Adaptive biased coin randomization (urn method)
- Big-stick rule
- Biased-coin with imbalance tolerance
- Nash-equilibrium-based randomization (1)
- Nash-equilibrium-based randomization (2)
- Nash-based procedure for MTI = 2, k = 1/8, N = 8
- The maximal procedure (MP)
- MP: each allowable path is equally likely
- MP: resulting probabilities for N = 8, MTI = 2
- The maximal procedure: conclusions
- Part 2: covariate-adaptive randomization
- Covariate-adaptive randomization
- Minimization (Taves)
- Biased-coin minimization (Pocock and Simon)
- Hierarchical covariate-adaptive methods
- Optimal biased-coin covariate-adaptive methods
- Part 3: response-adaptive randomization (RAR)
- Play-the-winner (Zelen)
- Modified play-the-winner
- Randomized play-the-winner (1)
- Randomized play-the-winner (Wei & Duham)
- Randomized play-the-winner (2)
- Objections to RAR methods
- Conclusions
- References (1)
- References (2)
Topics Covered
- Obstacles to standard methods of restricted randomization
- Biased coin methods
- Nash equilibrium
- The maximal procedure
- Covariate adaptive methods
- Response adaptive randomization
- Predictability and the potential for selection bias
- Efficiency of treatment effect estimators
- Patient welfare issues
- Optimal randomization
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Talk Citation
Grant, W. (2007, October 1). Novel methods for randomizing [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 13, 2024, from https://doi.org/10.69645/SBUD6323.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. William Grant has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.