Gammaretroviral vectors: biology, design and applications

Published on November 4, 2014 Updated on November 6, 2014   44 min

Other Talks in the Series: Gene Transfer and Gene Therapy

0:00
Hello. My name is Axel Schambach, and I'm the acting director of the Institute of Experimental Hematology at Hannover Medical School. Within the next 40 to 45 minutes or so, I would like to give you a broad overview on gammaretroviral vectors, their biology, their design, and their applications in clinical trials.
0:23
I will structure my presentation as follows. I will start with an introduction into the biology of retroviruses, including their genome and particle organization and the retroviral life cycle. From there I will give some insights how retroviruses have developed as evolutionary adapted vehicles to deliver genetic information. As a next step, we will convert a retrovirus into the retroviral vector gene delivery tool and mention how this vector system has been efficiently used in the clinical gene therapy arena. We will also touch the occurred adverse events and how these would potentially be prevented in future gene therapy trials. And mention the development of SIN vectors and how to create the right therapeutic window for gene therapy. Apart from the integrating retroviral vectors, we will also mention retroviral intermediates as delivery tools for genetic information. And also in the end take you a little bit on a time journey into the field of retroviral gene therapy and how it has developed. Finally, I will conclude with a summary and a take-home message.
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Gammaretroviral vectors: biology, design and applications

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