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- Epidemiology and Risk Factors
-
1. The changing prevalence of asthma
- Dr. Deborah Jarvis
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2. Recent advances in asthma genetics
- Prof. Miriam Moffatt
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3. Asthma: an epidemic caused by epigenetics?
- Prof. David Schwartz
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4. Role of the microbiota in asthma
- Prof. B. Brett Finlay
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5. Diet and asthma
- Prof. Lewis Smith
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6. Obesity and asthma
- Prof. Anne Dixon
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7. Occupational asthma: management beyond the textbooks
- Prof. Paul Cullinan
- Clinical Phenotypes
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8. The origins of asthma
- Prof. Peter Sly
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9. Pre-school wheeze
- Prof. Andrew Bush
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11. Smoking asthmatics
- Prof. Neil Thomson
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12. Aspirin exacerbated respiratory disease
- Prof. Chris Corrigan
- Mechanisms of Asthma
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13. Advances in asthma: airway inflammation
- Prof. William Busse
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14. The role of mast cells in asthma
- Prof. Peter Bradding
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15. Dendritic cells in asthma
- Prof. Bart Lambrecht
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16. The airway smooth muscle in asthma
- Prof. Judith Black
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17. Role of virus infection in asthma 1
- Prof. Sebastian Johnston
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18. Role of virus infection in asthma 2
- Prof. Sebastian Johnston
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19. Severe asthma: characterisation, mechanisms & treatment
- Prof. Fan Chung
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20. Steroid resistance in asthma: mechanisms and potential therapies
- Prof. Ian Adcock
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21. Macrophage in asthma
- Prof. Douglas Robinson
- Diagnosis of Asthma
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22. Physiology of asthma and involvement of small airways
- Prof. Charles G. Irvin
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23. Induced sputum in asthma
- Prof. Antonio Spanevello
- Therapy and Management
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25. Pulmonary drug delivery
- Prof. Anthony J. Hickey
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26. The management of chronic asthma
- Prof. Mark Fitzgerald
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27. Inhaled corticosteroids and beta2-agonists
- Dr. Omar S. Usmani
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28. Management of "difficult asthma"
- Prof. Elisabeth Bel
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29. Management of acute exacerbations of asthma
- Dr. Chris Fanta
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30. Non-pharmacological treatments for asthma
- Prof. Neil Thomson
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31. Asthma: beyond the prescription
- Prof. Martyn Partridge
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32. New drugs for asthma
- Prof. Peter Barnes
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33. Anti-IgE therapy for asthma
- Dr. Andrew Menzies-Gow
- Archived Lectures *These may not cover the latest advances in the field
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34. New drugs for asthma
- Prof. Peter Barnes
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35. Asthma phenotypes in children
- Prof. Andrew Bush
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36. Steroid resistance in asthma: mechanisms and potential therapies
- Prof. Ian Adcock
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37. Severe asthma in children
- Prof. Andrew Bush
Printable Handouts
Navigable Slide Index
- Introduction
- COI Statement
- What is 'asthma'?
- Redefining airways diseases
- Context: what IS this thing called asthma?
- Deconstructing the airway
- First tings first: get the basics right
- Unresponsive asthma?
- Get the basics right: measure!
- Evidence for asthma?
- Asthma is over-diagnosed
- How much SOBOE is due to asthma?
- Beyond medications: getting the basics right (1)
- Adherence
- Electronic monitoring
- Beyond medications: getting the basics right (2)
- PSA: MDT evaluation
- ‘Refractory difficult asthma’?
- Refractory difficult asthma
- Refractory asthma plus (1)
- Refractory asthma plus (2)
- Videotaping for DX VCD
- VCD: cycling
- EIB vs. VCD/EILO vs. Obesity
- Let's get SMART
- A paradox, a paradox, a most ingenious paradox
- SMART: adults and CYP>12
- SMART: results
- SMART age 6-11
- Meta-analysis - ICS/LABA rescue
- TREXA
- TREXA: safety
- ASIST
- Asthma attacks: more than mere 'exacerbations'
- Risks of asthma attacks?
- SABAs?
- What did they say?
- GINA: What’s old, what’s new?
- A never event?
- Beyond chronic steroid use: what are the options?
- DREAM on: Mepolizumab
- What biologics are available?
- Omalizumab
- Mepolizumab in paediatric severe asthma
- Voyager: Dupilumab
- Voyager: Dupilumab (2)
- Eosinophil count
- Are mechanisms the same in kids?
- SARP data
- TH1 STRA?
- STRA and allergy
- What about infection risk?
- Infections?
- Also not always the bad guys
- COVID and eosinophil count
- Where are we with monoclonals?
- Treatment of severe asthma
- Summary and conclusions
- Take-home messages
- Acknowledgements
- Thank you
Topics Covered
- The definition of asthma
- How to measure for asthma
- The over-diagnosis of asthma
- How adherence, environment and psychosocial factors affect asthma sufferers
- SMART
- Different treatments for asthma
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Bush, A. (2022, September 29). Updates on the management of difficult asthma in school-aged children [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/FBQV5245.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Andrew Bush has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Updates on the management of difficult asthma in school-aged children
Published on September 29, 2022
50 min
A selection of talks on Respiratory Diseases
Transcript
Please wait while the transcript is being prepared...
0:00
Thank you very much for
coming online to listen to
this update on the management of
difficult asthma in
school-aged children.
My name's Andrew Bush.
I'm a Professor of Paediatrics
at Imperial College
and the Royal Brompton Hospital.
0:15
I have no personal or
institutional conflict
of interest with regard
to this presentation.
0:22
The first part of this
talk, what is 'asthma'?
How do we define asthma?
What are we talking about here?
0:30
This is the Lancet Commission,
which I had the honour of
co-chairing with Ian Pavord.
One of the things that
we wanted to do in this
commission was revolutionise
airway disease
and deliver precision medicine.
What does that look like
in the context of asthma?
0:48
What is this thing
called asthma?
Is it airway inflammation?
Is it variable
airflow obstruction?
Is it bronchial
hyper-responsiveness?
A doctor said so?
I was once given an inhaler?
Or what is it?
Now, like the best
children's games,
every answer is correct.
All these definitions are used.
But our contention
is that asthma is
an umbrella term for wheeze,
dyspnoea, chest-tightness,
possibly with extra cough.
It's an umbrella term.
Just as anaemia is
an umbrella term
for low haemoglobin,
and arthritis is
an umbrella term
for hot red painful joints.
'Asthma' is the start,
not the finish of the
diagnostic journey.
If you say to the child,
"You have asthma,"
questions should come back.
What sort of asthma Is it?
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