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1. Introduction
2. Human retroviruses
3. Endemic areas of HTLV-I infection
4. HTLV-I: associated clinical disorders
5. HAM/ TSP
6. ATLL clinical/epidemiological features
7. ATLL pathological and immunological features
8. A flower cell
9. Cutaneous infiltrates in ATLL (1)
10. Cutaneous infiltrates in ATLL (2)
11. Typical histopathological of lymphoma
12. Cell proliferation and transformation by HTLV-I Tax
13. HTLV-I Tax and NF-kappa B activation
14. NF-kappa B activation in patients with ATLL
15. Development of ATLL
16. Established HTLV-I Tax-transgenic mouse models
17. Generation of Tax transgenic mice
18. Summary of initial study of transgenic mice
19. Estimation of Tax DNA copy number
20. Tax integration sites-genome walking analysis
21. Gross pathological findings
22. Histological findings (1)
23. Histological findings (2)
24. Peripheral blood: leukemic cells
25. Histological findings: P. jiroveci pneumonia
26. NF-kappa B activation in Tax Tg mice
27. Transfer of Tg Tax ATLL disorder to SCID mice
28. SCID mice peripheral blood
29. SCID mice histology
30. Flow cytometry analysis
31. Effect of lck promoter on T-cell phenotype
32. Affymetrix microarray data
33. Conclusions (1)
34. HTLV-II infection in American Indian populations
35. HTLV-II infection in IDUs
36. HTLV-II phylogenetic tree
37. HTLV Tax heterogeneity
38. HTLV-II molecular epidemiology
39. HTLV type II: oncogenic properties of Tax
40. Conclusions (2)

Topics Covered

• Human retroviruses
• HTLV-1
• HTLV-2
• Epidemiology of infection
• Clinical features of infection
• Adult T-cell leukemia/lymphoma (ATLL)
• Molecular pathogenesis of ATLL
• Transgenic mouse model of ATLL

Links

Series:

• Retroviruses

Categories:

• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Hall, W. (2007, October 1). The first human retroviruses: the human T lymphotropic viruses (HTLVs) [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2025, from https://doi.org/10.69645/XNST4194.
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Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Prof. William Hall has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.