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Navigable Slide Index

1. Introduction
2. Viral etiology of cancer
3. HTLV-1 genomic organization
4. Worldwide distribution of HTLV-1
5. HTLV-1 and disease
6. HTLV-1 receptor
7. HTLV1- GLUT1 interaction
8. Typical staining pattern of leukemic cells
9. Cutaneous manifestations of ATL
10. HTLV-1 Tax
11. Transgenic mice overexpressing Tax
12. Differential gene expression in the presence of Tax
13. Tax activates multiple cellular genes
14. Contributory effects: cell cycle dysregulation
15. Interactions of Tax with cell-cycle factors
16. Tax accelerates cell-cycle progression
17. Effect of Tax on CDK5
18. Activation of NF-kappaB by Tax
19. Activation of Akt/PKB by Tax
20. Normal and Tax-overexpressing muscle cells
21. Contributory effects: tumor suppressors repression
22. Interaction of Tax with p53
23. Effect of Tax on p53 activity
24. Inactivation of Rb by Tax
25. Measuring DNA damage by in-situ staining
26. Contributory effects: enhanced genetic instability
27. Chromosomal instability
28. Mitotic checkpoint
29. Inactivation of mitotic checkpoint by HTLV-1
30. Maintenance of chromosomal segregation fidelity
31. Tax associates with centrosomes
32. Tax causes centrosome fragmentation
33. Human cells transfected with Tax
34. Future challenges
35. microRNA and cancer (1)
36. microRNA and cancer (2)
37. Microarray of human miRNA
38. Summary
39. The paradox of ATL development

Topics Covered

• HTLV-1 epidemiology
• Virus infectivity of T lymphocytes
• Description of adult T-cell leukemia
• Details of mechanisms used by virus for oncogenesis

Links

Series:

• Retroviruses

Categories:

• Cancer
• Microbiology

Therapeutic Areas:

• Infectious Diseases
• Oncology

Talk Citation

Jeang, K. (2007, October 1). Human T-cell leukemia virus type 1 (HTLV-1) and adult T-cell leukemia: insights into cellular transformation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/UNNZ8427.
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Publication History

• Published on October 1, 2007
• Archived on October 28, 2018

Financial Disclosures

• Prof. Kuan-Teh Jeang has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.