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- Fundamental aspects
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1. Inflammation and tissue homeostasis
- Prof. Herman Waldmann
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2. Introduction to the immune system
- Prof. Herman Waldmann
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3. Hematopoiesis: the making of an immune system
- Prof. Paul J. Fairchild
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4. Inflammation: purposes, mechanisms and development
- Prof. Pietro Ghezzi
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5. Phagocytosis
- Dr. Eileen Uribe-Querol
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6. Regulated cell death mechanisms and their crosstalk with the immune system 1
- Dr. Luis Alberto Baena-Lopez
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7. Regulated cell death mechanisms and their crosstalk with the immune system 2
- Dr. Luis Alberto Baena-Lopez
- Innate immunity
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11. Cells of the innate immune system
- Prof. Kevin Maloy
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12. Microbial recognition and the immune response
- Dr. Dana Philpott
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13. Toll-like receptor signalling during infection and inflammation
- Prof. Luke O'Neill
- Intercellular mediators
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14. Chemokines
- Dr. James E. Pease
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15. Cytokines
- Prof. Iain McInnes
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16. IL-1 family cytokines as the canonical DAMPs of the immune system
- Prof. Seamus Martin
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17. Glycoimmunology
- Prof. Paula Videira
- Adaptive immunity B cells
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20. Antigen recognition in the immune system
- Prof. Herman Waldmann
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21. B cell biology
- Prof. Richard Cornall
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22. Antibody structure and function: antibody structure
- Dr. Mike Clark
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23. Antibody structure and function: antibody function
- Dr. Mike Clark
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24. Antibody genes and diversity
- Dr. Mike Clark
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25. In vivo antibody discovery and hybridoma technology
- Prof. Dr. Katja Hanack
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26. Antibody engineering: beginnings to bispecifics and beyond
- Dr. Ian Wilkinson
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28. The immunobiology of Fc receptors
- Prof. Mark Cragg
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29. Immunoreceptors
- Prof. Anton van der Merwe
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30. Affinity, avidity and kinetics in immune recognition
- Prof. Anton van der Merwe
- Adaptive immunity T cells
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31. The thymus and T cell development: a primer
- Prof. Georg Holländer
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32. Lineage decisions in the thymus: T cell lineage commitment
- Prof. Bruno Silva-Santos
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33. Lineage decisions in the thymus: αβ and γδ T cell lineages
- Prof. Bruno Silva-Santos
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34. CD4 T cell subsets
- Dr. Brigitta Stockinger
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35. Cytotoxic T lymphocytes
- Prof. Gillian Griffiths
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36. Gamma delta T-cells
- Prof. Bruno Silva-Santos
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37. Tfh and Tfr cells
- Prof. Luis Graca
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38. Tissue resident memory T cells (TRM)
- Dr. Marc Veldhoen
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39. Mathematical modeling in immunology
- Prof. Ruy M. Ribeiro
- The importance of the MHC in immunity
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40. The MHC and MHC molecules 1
- Prof. Jim Kaufman
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41. The MHC and MHC molecules 2
- Prof. Jim Kaufman
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42. Natural killer cells
- Dr. Philippa Kennedy
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44. NK cells in viral immunity
- Prof. Lewis Lanier
- Lymphocyte activation
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45. Signal transduction by leukocyte receptors
- Dr. Omer Dushek
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46. Immunological memory 1
- Prof. David Gray
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47. Immunological memory 2
- Prof. David Gray
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48. Studying immune responses “one cell at a time”
- Dr. Mir-Farzin Mashreghi
- Major cellular partners in immunity
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49. The mononuclear phagocyte system - tissue resident macrophages: distribution and functions
- Prof. Emeritus Siamon Gordon
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50. The mononuclear phagocyte system: tissue resident macrophages - activation and regulation
- Prof. Emeritus Siamon Gordon
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51. Dendritic cells: professional antigen presenting cells
- Prof. Paul J. Fairchild
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52. Mucosal immunology
- Prof. Daniel Mucida
- Immunological tolerance and regulation
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53. Self-tolerance
- Prof. Herman Waldmann
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54. Tolerance and autoimmunity
- Prof. Emerita Anne Cooke
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55. The balance between intestinal immune homeostasis and inflammation
- Prof. Dr. Janneke Samsom
- Translational immunology - immune deficiency
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56. Primary immunodeficiency disorders
- Dr. Smita Y. Patel
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57. Changes in innate and adaptive immunity during human ageing 1
- Dr. Roel De Maeyer
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58. Changes in innate and adaptive immunity during human ageing 2
- Dr. Roel De Maeyer
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59. The aging immune system
- Prof. Ana Caetano
- Translational immunology - protection against pathogenic microbes
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60. Immune responses to viruses
- Prof. Paul Klenerman
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61. HIV and the immune system
- Prof. Quentin Sattentau
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62. COVID-19: the anti-viral immune response
- Prof. Danny Altmann
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63. Bacterial immune evasion
- Prof. Christoph Tang
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64. The immunology underlying tuberculosis
- Prof. Thomas R. Hawn
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65. Innate immunity to fungi
- Prof. Gordon D. Brown
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66. Parasite immunity: introduction and Plasmodium
- Dr. Catarina Gadelha
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67. Parasite immunity: Leishmania and Schistosoma
- Dr. Catarina Gadelha
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68. Vaccination
- Dr. Anita Milicic
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69. The history of vaccines 1
- Prof. Emeritus Anthony R. Rees
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70. The history of vaccines 2
- Prof. Emeritus Anthony R. Rees
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71. The history of vaccines 3
- Prof. Emeritus Anthony R. Rees
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72. The science of vaccine adjuvants
- Dr. Derek O'Hagan
- Translational immunology - hypersensitivity, autoimmune disease and their management
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73. Hypersensitivity diseases: type 1 hypersensitivity
- Prof. Herman Waldmann
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74. Innate lymphoid cells in allergy
- Prof. Emeritus Shigeo Koyasu
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75. Hypersensitivity diseases: type II-IV hypersensitivity
- Prof. Sara Marshall
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76. B cells at the crossroads of autoimmune diseases
- Dr. Xiang Lin
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77. Interleukin-17: from clone to clinic
- Prof. Leonie Taams
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78. Autoimmunity and type 1 diabetes
- Prof. Emerita Anne Cooke
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79. What is new in type 1 diabetes?
- Prof. Åke Lernmark
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80. Antibodies to control or prevent type 1 diabetes
- Dr. Robert Hilbrands
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81. Monoclonal antibodies in haemato-oncology
- Prof. Mark Cragg
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82. Therapeutic antibodies
- Dr. Geoffrey Hale
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83. Neuroimmunometabolism
- Prof. Ana Domingos
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84. The immunology of multiple sclerosis
- Dr. Joanne Jones
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85. Understanding myasthenia gravis and advances in its management
- Prof. Henry J. Kaminski
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86. The immunology underlying rheumatic diseases
- Dr. Hussein Al-Mossawi
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88. Complement and lupus
- Prof. Marina Botto
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89. Immune mechanisms in liver diseases
- Prof. Paul Klenerman
- Translational immunology - transplantation immunology
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90. Principles of transplantation: overview of the immune response
- Prof. Emerita Kathryn Wood
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91. Factors influencing outcomes in clinical transplantation 1
- Prof. Emerita Kathryn Wood
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92. Factors influencing outcomes in clinical transplantation 2
- Prof. Emerita Kathryn Wood
- Translational immunology - cancer immunology
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93. Cancer immunology
- Prof. Tim Elliott
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94. Cancer immunotherapy
- Prof. Tim Elliott
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95. Myeloid-derived suppressor cells in cancer
- Prof. Dmitry Gabrilovich
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96. IL-2 in the immunotherapy of autoimmunity and cancer
- Prof. Thomas Malek
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97. Latest advances in the development of CAR & TCR T-cell treatments for solid tumours
- Dr. Else Marit Inderberg
Printable Handouts
Navigable Slide Index
- Introduction
- Homeostasis
- 1908 Nobel Prize
- Elie Metchnikoff
- Reticulo-endothelial system
- Mononuclear phagocyte system (MPS)
- Significant figures in macrophage research
- Dendritic cells
- 2011 Nobel Prize
- Microbiology spectrum: Individual chapters
- Macrophage differentiation and activation
- Sensing the environment: MØ response
- Macrophage receptors
- Kupffer cells F4/80+
- The EGF-TM7 family - adhesion GPCRs
- Schematic distribution of F4/80 staining
- Human bone marrow haemopoietic islands
- Haematopoietic stroma
- Trophic interactions: Haematopoiesis
- Clustering of CD169
- F4/80 in mouse spleen
- Sinusoidal immunity
- Differentiation microglia
- Heterogeneity of macrophages in the brain
- Microglial functions
- Macrophages and peripheral nervous system
- Sympathetic neuron associated macrophages
- Macrophage heterogeneity - transcriptomes
- Macrophages and thermogenesis
- Macrophages and the heart
- Phagocytosis imprints heterogeneity
- Cavity macrophages and tissue repair
- Peritoneal macrophages and host defence
- Osteoclasts
- Cell fusion and macrophage differentiation
- Summary
- Thank you for listening
Topics Covered
- History of macrophages
- Phagocytosis
- Receptors of macrophages
- Macrophage differentiation and activation
- Diverse populations of macrophages
- The distribution and function of macrophages
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Gordon, S. (2021, December 12). The mononuclear phagocyte system - tissue resident macrophages: distribution and functions [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 23, 2024, from https://hstalks.com/bs/4553/.Export Citation (RIS)
Publication History
Financial Disclosures
- Siamon Gordon recieves Honoraria from Verseau Therapeutics and Myeloid Therapeutics. He has recieveid royalties from Thermo Fisher Scientific, and is involved in Bio-Rad sales.
The mononuclear phagocyte system - tissue resident macrophages: distribution and functions
Published on December 12, 2021
56 min
A selection of talks on Immunology
Transcript
Please wait while the transcript is being prepared...
0:00
I'm Siamon Gordon. I'm at the Sir William Dunn School of Pathology in Oxford.
I'm going to talk about macrophages in two parts today.
First, the mononuclear phagocyte system, which I'll explain later.
I'll discuss the tissue-resident macrophages,
their distribution throughout the body, and their functions.
Then, in Part 2, which is to follow, I'll be talking about
the same system but the tissue recruited macrophages, their activation, and regulation.
0:33
The context of macrophage physiology and pathology is very much based
on homeostasis which is maintaining a steady state.
First, the concept was introduced by Claude Bernard in the 19th century and
I can recommend a very good experimental introduction by him republished by Dover Publications.
But the term homeostasis was derived from Walter Cannon an American physiologist
and there's a book that he's written called
The Wisdom of the Body that I would also recommend to students.
The point I wanted to make is that it's an active process to maintain
the steady-state, the milieu intérieur as Claude Bernard initially described it.
It actually is on the physiological and pathological level when homeostasis breaks down.
1:27
The grandfather of the field of macrophages is Élie Metchnikoff shown on the left here,
and he is known for the discovery of phagocytosis,
macrophage properties and he and Paul Ehrlich
received the Nobel Prize in 1998 for their work on immunity,
Metchnikoff for cellular immunity and Paul Ehrlich for humoral immunity.
Now there was a conflict between these two but it
turned out that both were correct and each interacts
with the other system and the Nobel Prize award tried to reconcile
these two rather disparate views of
immunology current at the time and very controversial at the time.
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