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- Function of important examples of PTK receptor families
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1. The molecular basis of insulin action
- Prof. Morris White
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2. The Eph receptor family
- Prof. Elena Pasquale
- Structure of PTK receptors and regulation of their kinases
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3. EGF receptor family: targets for improving cancer therapy
- Prof. Tony Burgess
- Intracellular signal transduction by PTK receptors
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4. PI 3-kinases and lipid messengers
- Prof. Bart Vanhaesebroeck
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5. RTKs activate the ERK 1/2 MAPK cascade
- Prof. Melanie H. Cobb
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6. The ERK1/2 MAPK cascade
- Prof. Melanie H. Cobb
- Archived Lectures *These may not cover the latest advances in the field
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7. Receptor tyrosine kinases - function, families and evolution
- Prof. Tony Hunter
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9. How the PDGF receptor induces cell proliferation
- Dr. Andrius Kazlauskas
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10. VEGF inhibitors for anti-angiogenic therapy
- Prof. Kari Alitalo
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12. Activation of PTK receptors in solid human tumors
- Dr. Marco Pierotti
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14. SH2-containing PTPs (Shps) in RTK signaling and disease
- Prof. Benjamin G. Neel
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16. Phospholipase C Gamma
- Prof. Graham Carpenter
- Ms. Cornelia Crooke
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17. Imatinib as a paradigm of targeted cancer therapies
- Prof. Brian Druker
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18. EGFR targeted therapies in lung cancer
- Dr. Pasi Janne
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19. The VEGF family
- Prof. Kari Alitalo
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20. The HGF receptor, a targettable regulator of invasive growth
- Prof. Paolo Comoglio
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21. Structural biology of FGF signaling in human development and disease
- Dr. Moosa Mohammadi
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22. EGF receptor family: targets for cancer therapeutics
- Prof. Tony Burgess
Printable Handouts
Navigable Slide Index
- Introduction
- Mechanisms to diabetes
- The insulin response
- Growth factor receptor tyrosine kinases
- Insulin and its receptor
- Insulin receptor
- Insulin receptor transmembrane signaling
- Insulin and IGF1 receptors exist as hybrids
- Growth factor receptor tyrosine kinases
- The substrate hypothesis of insulin action
- The family of Irs-proteins
- Insulin signaling cascade
- Insulin stimulates GLU4 translocation
- The insulin signaling cascade
- The insulin signaling cascade inhibition
- IRS-proteins mediated insulin action
- IRS2 integrates central & peripheral homeostasis
- IRS2 regulates hepatic glucose homeostasis
- IRS2 signaling promotes glucose homeostasis
- IRS signaling regulates the expression of Pdx-1
- Integrated view of IRS signaling system
Topics Covered
- Mechanisms to diabetes
- The insulin response
- Growth factor receptor tyrosine kinases
- The insulin receptor
- The substrate hypothesis of insulin action
- The family of Irs-proteins
- The insulin signaling cascade
- Role of the Irs2 signaling system
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
White, M. (2007, October 1). The molecular basis of insulin action [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 27, 2024, from https://hstalks.com/bs/449/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Morris White has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.