Oxidative stress and disease: atherosclerosis

Published on September 26, 2019   54 min

Other Talks in the Therapeutic Area: Immunology & Inflammation

0:00
The title of this presentation is Oxidative stress and Disease: Atherosclerosis. My name is Giuseppe Poli from the Department of Clinical and Biological Sciences, University of Turin, Italy. I would like to present and discuss the recent available evidence on the possible role of oxidative stress in the pathogenesis of atherosclerosis.
0:30
Cellular oxidative stress is a biochemical phenomenon occurring under different conditions, and characterized by different intensities. Depending on the intensity of the biochemical phenomenon, we can have either modulation of cell functions or other physiological conditions, like fibrosis and inflammation. In case of a high intensity of oxidative stress, the cell develops irreversible damage.
1:09
In association with oxidative stress, chronic inflammation and fibrosis often occurs, in several chronic human diseases involving the lung, the liver, the brain or the kidney. Today we are interested in atherosclerosis, a term which is actually composed of two words: 'atheroma' and 'sclerosis'. Atheroma means fibrotic plaque, sclerosis is a similar term to fibrosis, and they mean the fibrotic degeneration of the arterial wall.
Hide

Oxidative stress and disease: atherosclerosis

Embed in course/own notes