The title of this presentation
is Oxidative stress and
My name is Giuseppe Poli from
the Department of Clinical and
University of Turin, Italy.
I would like to present and
discuss the recent available evidence
on the possible role of oxidative stress
in the pathogenesis of atherosclerosis.
Cellular oxidative stress is
a biochemical phenomenon occurring
under different conditions, and
characterized by different intensities.
Depending on the intensity of
the biochemical phenomenon,
we can have either modulation
of cell functions or
other physiological conditions,
like fibrosis and inflammation.
In case of a high intensity
of oxidative stress,
the cell develops irreversible damage.
In association with oxidative stress,
chronic inflammation and
fibrosis often occurs,
in several chronic human diseases
involving the lung, the liver,
the brain or the kidney.
Today we are interested in
atherosclerosis, a term which is
actually composed of two words:
'atheroma' and 'sclerosis'.
Atheroma means fibrotic plaque,
sclerosis is a similar term to fibrosis,
they mean the fibrotic
degeneration of the arterial wall.