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Printable Handouts
Navigable Slide Index
- Introduction
- Heliotherapy and the immune system
- Vitamin D sources
- Vitamin D synthesis and metabolism
- Actions of active vitamin D on peripheral tissues
- Vitamin D deficiency - definition
- Views about sun exposure in the past
- Current views about sun exposure
- Vitamin D levels in healthy subjects from Israel
- Aren't we all vitamin D deficient?
- Vitamin D deficiency in autoimmune patients
- Vitamin D, immune cells and mediators
- Vitamin D in systemic lupus erythematosus (SLE)
- Epidemiology: SLE patients
- Vitamin D receptor polymorphism in SLE patients
- Vitamin D deficiency and disease activity
- Vitamin D deficiency and SLE comorbidities
- Vitamin D and markers in SLE
- Vitamin D levels predict disease progression
- Vitamin D status and transition to SLE
- Sunlight avoidance in SLE patients
- Interventional studies in SLE (1)
- Interventional studies in SLE (2)
- Interventional studies in SLE (3)
- Vitamin D and type 1 diabetes mellitus (T1DM)
- Epidemiology: T1DM and vitamin D deficiency
- Seasonal variation in T1DM diagnosis
- Maternal vitamin D levels & T1DM in child
- Vitamin D deficiency during early life and T1D
- Vitamin D metabolism genes and T1DM
- Vitamin D deficiency and T1DM complications
- Interventional studies in T1DM
- Vitamin D and multiple sclerosis (MS)
- Epidemiology: vitamin D and multiple sclerosis
- Epidemiology: seasonal variation in MS
- Vitamin D deficiency and risk for MS
- Maternal vitamin D levels & the risk of MS in child
- Vitamin D deficiency and MS activity
- Interventional studies in MS
- Vitamin D and rheumatoid arthritis (1)
- Vitamin D and rheumatoid arthritis (2)
- Vitamin D and other autoimmune diseases
- Vitamin D intake for patients at risk for deficiency
- Effect of daily vitamin D supplementation
- Vitamin D toxicity
- In conclusion
- Thank you for your attention!
Topics Covered
- Introduction to heliotherapy
- Vitamin D sources and metabolism
- Vitamin D deficiency and its epidemiology
- Vitamin D and SLE
- Vitamin D and type 1 diabetes
- Vitamin D and MS
- Vitamin D and rheumatoid arthritis
- Vitamin D and other autoimmune diseases
- Vitamin D supplementation
- Vitamin D toxicity
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Talk Citation
Azrielant, S. (2018, December 30). Vitamin D and autoimmunity [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 7, 2024, from https://doi.org/10.69645/KKAM1664.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Shir Azrielant has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Metabolism & Nutrition
Transcript
Please wait while the transcript is being prepared...
0:00
Hello. My name is Shir Azrielant from
the Zabludowicz Center for Autoimmune Diseases in Sheba Medical Center of Israel.
Today, I'm going to talk to you about "Vitamin D and Autoimmunity'.
0:14
Heliotherapy, meaning light therapy,
has been used since the ages of ancient Egypt, Greece,
and Rome, where sunlight was used to treat various medical conditions.
In the modern age,
Dr. Niels Ryberg Finsen was the first to use light radiation as treatment,
specifically in infectious skin diseases.
For which he was awarded the Nobel Prize in physiology and medicine in 1903.
In a study from 1983,
the immunological effects of solarium exposure were documented.
These and other studies have laid
the foundation for the modern researcher for the effect of
vitamin D on the immune system in general and on immunomodulation in particular.
0:57
The main source for vitamin D comes from
its biosynthesis in the skin in response to ultraviolet exposure.
In regards to dietary sources,
very few foods naturally contain
vitamin D. Fatty fish are relatively rich in the vitamin,
and small amounts of it can be found in shiitake mushroom and egg yolks.
Several foods are fortified with vitamin D,
including milk and its products,
orange juice, infant formulas, and breakfast cereals.
Vitamin D can also be consumed as a dietary supplement in one of two forms: D2 and D3.
1:34
Vitamin D synthesis and metabolism.
Ultraviolet B radiation penetrates uncovered skin
and converts 7-dehydrocholesterol to pre-vitamin D3,
which in turn becomes vitamin D3.
Vitamin D may also be obtained from dietary sources or supplements.
Vitamin D3 binds to vitamin D binding proteins,
DBP, in the bloodstream,
and then activated first in the liver to become 25-hydroxy vitamin D,
and then in the kidney to 125-dehydroxy
vitamin D. The activated vitamin D binds to intracellular vitamin D receptor,
VDR, and its target tissues.