Hi, this is Fei Ye,
from Vanderbilt University Medical Center.
In the second part of my lecture,
I will be focusing on using the Bayesian methods to design phase II clinical trials.
As I mentioned at the previous lecture,
adaptive designs have emerged rapidly during the last two decades.
But mostly with Frequentist approach,
often as an effective way to speed up the evaluation process because of
the flexibility and the more intuitive way
of interpreting the results with Bayesian methods.
Many Bayesian designs have also been
proposed and conducted for phase II clinical trials.
However, it has been reported that they are still poorly used in
practice mainly because many clinicians do not fully understand the Bayesian methods.
So, many statisticians, as well as clinicians,
are putting a lot of effort into promoting
all phases of clinical trials to use Bayesian methods.
First, I'm going to explain the differences between a Bayesian and a Frequentist approach.
Then, I'm going to talk about Bayes' theorem,
the impact of prior distribution and then I will give an example of Bayesian trial,
and the last I will introduce the very new Bayesian basket design.