Hello, my name is Mark Conaway.
I'm a professor in the Division of Translational Research and Applied Statistics
in the Department of Public Health Sciences at the University of Virginia.
This talk is on patient heterogeneity in dose-finding trials.
Part 2 focuses on trials conducted in more than two groups.
There's also a part one that focuses on trial done in exactly two groups.
The outline for this talk is that I'll first provide
motivating examples for trials done in three or more groups.
Then I'll discuss some of
the existing statistical methods for the design of trials in three or more groups.
First was published by Yuan and Chappell in 2004.
Then, I'll talk about a couple of papers recently
published that discuss completely or partially ordered groups.
I'll define what I mean by
completely or partially ordered groups in the context to dose-finding.
A study done in four groups presented by Ramanathan et al in 2008.
Prior to assigning doses,
patients were grouped into categories based
on the degree of liver dysfunction at baseline.
Patients were grouped into either none,
mild, moderate, severe levels of liver dysfunction.
A similar grouping was used in a dose-finding study reported by LoRusso et al in 2012.