Design early phase drug combination trials: software

Published on May 29, 2017   33 min
0:00
Hello, I am Ying Yuan. I'm a professor in Biostatistics at MD Anderson Cancer Center. In the first part, we have talked about the three designs to find a single MTD or MTD contour. So in this part we're going to focus on how to implement those three designs using our existing software. So we are going to go through each of them and show you how to use the software to design specific trial examples.
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So right now, we switch to the software. So, so far we have talked about several designs to find the MTD or MTD contour. And from a practical point of view, the important thing is that we have the software to implement the design, and how can we use it in practice. So the important reason we chose those three designs is because it is very easy to use the software for those designs. And essentially they can be implemented using the R package "BOIN" available from the CRAN. And then in addition, if you don't like R, there is also Standalone, a graphic user interface-based software available from MD Anderson Biostatistics Software downloaded from the website. Here I give the link, if you are interested, you can download it. And in addition, we also provide a statistical tutorial and protocol template. So this is listed on my website - you can check it out.
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Design early phase drug combination trials: software

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