Adaptive clinical trials: overview 1

Published on August 31, 2017   38 min
0:00
Hello everyone. Welcome to the Adaptive Clinical Trials course. This is the first lecture, we call this the overview. And my name is Yu Shyr. I am the director at the Vanderbilt Center for Quantitative Sciences.
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In today's lecture, we will talk about several topics which is to highlight the adaptive clinical trial design for the entire course series. I will start to talk about the definition of an adaptive clinical trial and then I will follow by a Frequentist versus Bayesian versus likelihood. We know you can design an adaptive clinical trial based on the Frequentist-based or Bayesian-based or even likelihood-based. I will give you some highlights about the differences and similarities about those three big branches in statistical world. Followed by that, I will give you a very simple example of adaptive clinical trial design, which is I will give you a Bayesian and a Frequentist-based idea. And after that, I will give you an adaptive randomization trial based on the baseline covariates, introduce minimization, randomization for you. And then I will introduce the so-called biased urn study which is the adaptive randomization clinical trials based on the study outcome. I will end with the last topic which is the biomarker-adaptive clinical trial design. And I will come back to this biomarker adaptive clinical trial design when you complete the entire course training.