0:00
Hello everyone.
Welcome to the Adaptive Clinical Trials course.
This is the first lecture,
we call this the overview.
And my name is Yu Shyr.
I am the director at the Vanderbilt Center for Quantitative Sciences.
0:21
In today's lecture, we will talk about
several topics which is to highlight
the adaptive clinical trial design for the entire course series.
I will start to talk about the definition of
an adaptive clinical trial and then I will follow
by a Frequentist versus Bayesian versus likelihood.
We know you can design an adaptive clinical trial based on the
Frequentist-based or Bayesian-based or even likelihood-based.
I will give you some highlights about the differences and similarities about
those three big branches in statistical world.
Followed by that, I will give you
a very simple example of adaptive clinical trial design,
which is I will give you a Bayesian and a Frequentist-based idea.
And after that, I will give you an adaptive randomization trial based on
the baseline covariates, introduce minimization,
randomization for you. And then I will introduce the so-called biased urn study which is
the adaptive randomization clinical trials based on the study outcome.
I will end with the last topic which is the biomarker-adaptive clinical trial design.
And I will come back to
this biomarker adaptive clinical trial design when you
complete the entire course training.
