• General Virology
• 46 min
  1. Principles of virology

  • Prof. Vincent Racaniello
• 36 min
  2. The type I interferon system and viruses

  • Dr. Adolfo Garcia-Sastre
• 45 min
  3. Immune responses to viruses

  • Prof. Paul Klenerman
• Emerging Pathogens
• 29 min
  4. Emerging or newly discovered viral causes of acute lower respiratory tract infections worldwide

  • Dr. Marietjie Venter
  • Mrs. Orienka Hellferscee
• 37 min
  5. Emerging respiratory viruses - discoveries between 2001 and 2005

  • Prof. Ron Fouchier
• 28 min
  6. Usage of vaccines and therapeutics in public health emergencies 1

  • Prof. Gary Kobinger
• 39 min
  7. Usage of vaccines and therapeutics in public health emergencies 2

  • Prof. Gary Kobinger
• 50 min
  8. Influenza virus pandemics: past and future

  • Prof. Peter Palese
• 63 min
  9. SARS-CoV and other emerging coronaviruses

  • Prof. Ralph Baric
• 36 min
  10. Dengue, Zika and Chickungunya viruses

  • Prof. Ana Fernandez-Sesma
• 43 min
  11. Paramyxoviruses: biology & pathogenesis

  • Prof. Benhur Lee
• 36 min
  12. Antiviral drugs (non-HIV)

  • Prof. Megan Shaw
• 41 min
  13. Biodefense challenges

  • Dr. David Franz
• Important Pathogens and their Diseases
• 38 min
  14. Natural history and pathogenesis of herpes virus infections

  • Prof. Richard Whitley
• 40 min
  15. Cytomegalovirus biology

  • Prof. Domenico Tortorella
• 46 min
  16. Hepatitis C virus: discovery, cure and protection

  • Dr. Matthew Evans
• 32 min
  17. Fundamentals of HIV biology

  • Prof. Viviana Simon
• 44 min
  18. Measles

  • Prof. Diane E. Griffin
• 42 min
  19. Monkeypox virus, vaccines, and therapeutics

  • Prof. Rachel Roper
• New Frontiers
• 45 min
  20. HPV vaccines to prevent cervical cancer and other HPV-associated diseases

  • Dr. John Schiller
• 55 min
  21. Prevention of Varicella and Zoster by vaccination: Now you see it, now you don't

  • Prof. Anne Gershon
• 30 min
  22. Viruses as anticancer weapons

  • Prof. Roberto Cattaneo
• 48 min
  23. Novel approaches to diagnosis of viral infections

  • Prof. W. Ian Lipkin
• 36 min
  24. The Global Virus Network: collaboration to address pandemic and regional threats

  • Prof. Sten H. Vermund
• 31 min
  25. Elite controllers of HIV: from discovery to future therapies

  • Prof. Bruce Walker
• Archived Lectures *These may not cover the latest advances in the field
• 43 min
  26. Principles of virology I

  • Prof. Richard Condit
• 43 min
  27. Principles of virology II

  • Prof. Richard Condit
• 36 min
  28. Complex DNA viruses: herpes virus

  • Dr. John Blaho
• 38 min
  29. Adeno-associated viruses (AAV)

  • Prof. Kenneth Berns
• 60 min
  30. Poxviruses: smallpox (variola), vaccinia and monkeypox

  • Prof. Paula Traktman
• 26 min
  31. Can HPV testing be the sole primary cervical screening modality?

  • Prof. Jack Cuzick
• 29 min
  32. From viruses to oncolytics

  • Prof. Roberto Cattaneo
• 38 min
  33. Non HIV antivirals

  • Prof. Mary Klotman
• 42 min
  34. Gastroenteritis viruses

  • Prof. Mary Estes
• 46 min
  35. Biodefense challenges

  • Dr. Connie Schmaljohn
• 32 min
  36. Papillomaviruses and HPV vaccination to prevent cervical cancer and other HPV-associated diseases

  • Dr. Douglas Lowy
• 49 min
  37. The past, present and future of vaccination

  • Prof. Stanley Plotkin
• 41 min
  38. Filoviruses

  • Dr. Christopher Basler
• 41 min
  39. Bunyaviruses

  • Prof. Richard Elliott
• 41 min
  40. The immunobiology of HIV

  • Prof. Norman Letvin
• 59 min
  41. Hepatitis C and HCV

  • Prof. Stanley Lemon

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Adeno-associated virus (AAV)
3. AAV classification
4. AAV is a helper dependent parvovirus
5. AAV genetic map
6. AAV Rep proteins
7. Rep functions
8. AAV terminal repeat
9. ITR functions
10. AAV replication
11. Enzymes needed for AAV replication
12. AAV infection
13. Viral entry
14. AAV receptors
15. Illustration of AAV infection
16. VP1 has phosholipase A2 (PlA2) activity
17. Site-specific integration
18. TRP-186
19. AAVS1 (19q13.4)
20. Features of AAV integration
21. AAV for gene therapy
22. Ideal vector
23. How to make an AAV vector
24. Recombinant AAV virus preparation
25. How do you make a lot of vectors
26. Strategies
27. Do recombinant AAV vectors integrate?
28. Diseases targets for AAV
29. AAV in some clinical trials
30. Viral vectors in clinical trials
31. AAV features
32. Conclusions
33. From medical oddity to medical tool!

Topics Covered

• Adeno-associated virus
• Molecular biology
• Persistent infection
• Lack of pathogenicity
• Use as a vector for gene therapy
• Vector structure and properties
• Vector production
• Clinical trials

Links

Series:

• Viruses and Viral Diseases

Categories:

• Genetics & Epigenetics
• Methods
• Microbiology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on September 14, 2017

Financial Disclosures

• Prof. Kenneth Berns has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.