Biogenesis of cellular iron-sulfur proteins: structure, function, and assembly in mitochondria

Published on March 29, 2018   49 min
0:00
Hello, my name is Roland Lill, I'm a Professor of Cell Biology at the Institute of Zytobiologie at the Philipps- Universitat of Marburg, in Germany. In my lecture, I will try to give you an overview on what we learned over the past two decades on the Biogenesis of Cellular Iron-Sulfur Proteins in Eukaryotes.
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In part one of my lecture, I will first provide you with a general overview on the structure and function of Iron-Sulfur clusters and proteins in nature. Then I will briefly introduce you into the biochemical and spectroscopic methods of how we can analyze Iron-Sulfur proteins and their biogenesis. Next, I will concentrate on what we know about the mechanisms of the Iron-Sulfur protein assembly in mitochondria. This is then followed by a brief overview of the so-called mitochondrial Iron-Sulfur diseases. And finally, I will discuss a few open questions in this exciting research field. In part two, I will cover the role of mitochondrion and assembly. I will talk on cytosolic and nuclear Iron-Sulfur proteins, the mechanisms of this process and about a number of essential cellular processes intimately connected to cytosolic and nuclear Iron-Sulfur protein biogenesis.
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Biogenesis of cellular iron-sulfur proteins: structure, function, and assembly in mitochondria

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