Hello, my name is Roland Lill,
I'm a Professor of Cell Biology at
the Institute of Zytobiologie at the Philipps- Universitat of Marburg, in Germany.
In my lecture, I will try to give you an overview on what we learned over
the past two decades on the Biogenesis of Cellular Iron-Sulfur Proteins in Eukaryotes.
In part one of my lecture,
I will first provide you with a general overview on
the structure and function of Iron-Sulfur clusters and proteins in nature.
Then I will briefly introduce you into
the biochemical and spectroscopic methods of how
we can analyze Iron-Sulfur proteins and their biogenesis.
Next, I will concentrate on what we know about
the mechanisms of the Iron-Sulfur protein assembly in mitochondria.
This is then followed by a brief overview of
the so-called mitochondrial Iron-Sulfur diseases.
And finally, I will discuss a few open questions in this exciting research field.
In part two, I will cover the role of mitochondrion and assembly.
I will talk on cytosolic and nuclear Iron-Sulfur proteins,
the mechanisms of this process and about a number of
essential cellular processes intimately connected
to cytosolic and nuclear Iron-Sulfur protein biogenesis.