My name is Martin Brand from the Buck Institute for Research on Aging in Novato.
And I want to talk to you today about
Mitochondrial Production of Reactive Oxygen Species.
The next slide introduces that.
So what I'm going to tell you is that there are
many different sites within mitochondria which are
able to generate superoxide or hydrogen peroxide,
the reactive oxygen species I'm going to be talking about.
Their contributions change depending on the substrates and the conditions.
And under near-physiological conditions,
we think that at least in skeletal muscle, four sites dominate.
So, I'll talk about those four sites.
And then once we've characterized the sites and understood something of their properties,
I'll talk about our endeavors to suppress them, small molecule suppressors.
I'll introduce suppressors of electron leaked cells which can
prevent particular sites from running without affecting oxidative phosphorylation.
And then talk about how those tools allow us to
understand how the sites are operating in physiology and pathology.
So the next slide introduces the production of radicals.