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Printable Handouts
Navigable Slide Index
- Introduction
- Overview
- The complement marks pathogens as non-self
- Complement-mediated viruses neutralization (1)
- Complement-mediated viruses neutralization (2)
- The complement: a key defense against viruses
- Viruses subvert the host complement system
- 1. Complement subversion by molecular mimicry
- Viruses encode complement regulators (1)
- Viruses encode complement regulators (2)
- Complement regulatory activities of viral RCA
- The role of vaccinia virus protein VCP
- Poxviral complement regulators and viral tropism
- Viral complement regulation of Kaposica
- Herpesvirus Saimiri CD59
- Encoding unique complement regulators
- In vivo role of HSV gC-1: murine flank model
- Other examples of unique complement regulators
- 2. Complement subversion by molecular piracy
- Piracy of membrane bound host proteins
- Piracy of host membrane complement regulators
- Piracy of soluble host regulators
- 3. Complement protein subversion for cellular entry
- Employing complement proteins for cell entry (1)
- Employing complement proteiss for cell entry (2)
- Complement receptors and enhanced infection
- 4. Modulation of complement protein expression
- Upregulation of complement regulators
- HCV activity
- Summary
- Acknowledgements
Topics Covered
- Recognition of viruses by the complement system
- Role of complement in antiviral immunity
- Complement subversion by viruses: molecular mimicry, molecular piracy, use of complement receptors and regulators for cellular entry, and modulation of complement protein expression
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Sahu, A. (2018, January 31). Subversion of the complement system by viruses [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 10, 2024, from https://doi.org/10.69645/KMVQ3961.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Arvind Sahu has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: The Complement System
Transcript
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0:00
Hello, everybody.
I am Arvind Sahu.
I am a Scientist at the National Center for Cell Science, Pune, India.
In this talk, I will try to provide you
an overview on the "Subversion of the Complement System by Viruses".
0:17
I have divided my talk in three parts.
First, I will talk on how complement recognizes viruses,
then I will talk on what role complement plays in antiviral immunity,
and then, I will talk about various complement subversion mechanisms of viruses.
0:36
So the first question,
that comes to anybody's mind,
is how complement marks viruses as non-self?
And the simple answer is,
it does so by labeling them with C3b.
That is, once C3b is covalently attached to viruses,
it is considered as non-self by the complement system.
So let us see how this occurs.
So, when a virus enters our body,
it can be labelled by C3b,
by three different mechanisms, that is,
by the classical pathway,
by the lectin pathway,
and by the alternative pathway.
Activation of these pathways result in the formation of an enzyme,
termed C3 convertase, which cleaves C3 into C3a and C3b.
The C3b moiety ,
then gets covalently attached to the surface forming an ester or sometimes amide bond.
The position of C3b then results in the activation of the
alternative pathway loop leading to
the position of more C3b molecules on the viral surface.
This also results in the formation of C5 convertase,
which can result in the activation of the terminal pathway leading to the formation of the
membrane attack complex on the lipid membranes of viruses resulting in virolysis.