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Printable Handouts
Navigable Slide Index
- Introduction
- Innate and acquired immunity
- Biological functions of complement
- The complement system
- Three activation pathways
- Initiation of the classical pathway
- Activators of C1
- The classical pathway C3 convertase
- Covalent C3 deposition
- The classical pathway C3 and C5 convertases
- Membrane attack complex
- Dose-dependent effects of terminal complexes
- Anaphylatoxins
- Chemotactic factors
- Immune adherence
- Assessment of hemolytic activity
- Hemolytic assays for complement activity
- ELISA assays for complement activation pathways
- Functional diagnostics of complement by ELISA
- Deposition of immune complexes in the kidney (1)
- Immune complex (1)
- Immune complex (2)
- Elimination patterns
- Immune complex elimination in humans
- Extracellular part of CR1
- Role of erythrocyte CR1 on IC distribution
- Complement deficiency and autoimmunity
- Genetic deficiencies of complement components
- C1Q: the safe elimination of altered host cells
- Apoptotic cell processing and autoimmunity
- Systemic lupus erythematosus
- Deposition of immune complexes in the kidney (2)
- ELISA detects IgG antibodies against C1q
- IgG anti-C1q antibodies and lupus nephritis
- Control IgG2b monoclonal Ab
- JL-1: anti-C1q monoclonal Ab
- Regulation of complement activation
- Fluid phase complement regulators
- Membrane-bound complement regulators
- Deficiencies of fluid phase regulators and disease
- Conclusions
Topics Covered
- Three activation pathways of complement
- Initiation of the classical pathway
- Dose-dependent effects of terminal complement complexes
- Hemolytic assays and ELISA for quantification of complement activity
- Clearance of self-debris and of immune complexes
- Complement deficiency and autoimmunity
- Disturbed apoptotic cell processing
- Systemic Lupus Erythematosus
- Fluid phase and membrane-bound complement regulators
Links
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Talk Citation
Daha, M.R. (2017, December 31). The classical pathway of complement [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 9, 2024, from https://doi.org/10.69645/FOLE4949.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Mohamed R. Daha has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: The Complement System
Transcript
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0:00
Ladies and gentlemen, my name is Mohamed Daha.
I'm a professor emeritus at Leiden University Medical Centre,
and my email address is written below,
and so in case you'd like to contact me,
please feel free to do so.
So, in order to understand what the position of complement
is in our innate immune system and acquired defense,
I would like to give you a view what innate and acquired immunity is.
0:31
Innate immunity is the immunity by which your born with, except
the antibodies that you have received from
your mother via the placenta before or during birth.
Innate immunity is composed of a number of cells.
The first place NK cells, Macrophages,
Dendritic cells also known as antigen presenting cells and Granulocytes or PMNs.
Next to these cellular components,
there are a number of soluble mediators called Cytokines,
Chemokines, Defensins and Pentraxins.
And the main pillar in this soluble mediators is the complement system.
Complement is very important for the recognition of antigens.
This can directly be recognized by dendritic cells.
For instance, complement facilitates the recognition
and leads to a much better presentation of antigens to,
for instance, T lymphocytes and B lymphocytes.
T lymphocytes and B lymphocytes recognized the processed antigens and
then result in activated T cells and B cells leading to production of antibodies.
Next to production of antibodies and activated T cells,
there are a number of soluble products that you see,
Cytokines and chemokines which also directly affect and feed back to innate immunity.
So, as you see complement is very important in the sense that if, for instance,
if you are deficient in the complement system,
you are not really able to mount a sufficient and effective acquired immunity.
And many investigators have shown that deficiencies of complements are very
important for the mounting of
an efficient immune response and especially the production of antibodies.