General factors affecting drug metabolism: effect of physiological factors and disease 2

Published on July 31, 2017   24 min

Other Talks in the Series: Drug Metabolizing Enzymes

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We will now move on to the topic of drug metabolism in inflammatory disease states which, as we will see, is applicable to a wide variety of diseases in humans.
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The symptoms of inflammation were described more than two centuries ago by Celsus, tumor, rubor, calor and dolour, or, swelling, redness, heat and pain. These symptoms are the result of a local or systemic response to infection or injury designed to eliminate or control invading pathogens or to allow tissue recovery and repair following injury. But an exaggerated, inappropriate or chronic inflammatory response can be deleterious and many human diseases have an inflammatory component. Local inflammation is characterized by vasodilation, neutrophil recruitment and a cascade of pro-inflammatory cytokine and they cause node release. The triggering events of an inflammatory response are many and varied. But, in the case of infection usually result from the activation by microbial products of pattern recognition receptors such as Toll-like receptors on cells of the innate or adaptive immune systems. Physical or thermally-derived injuries initiate inflammation by activating mast cells in the tissues which release histamine and tumor necrosis factor alpha, again initiating the inflammatory cascade. Perhaps, the first indication that inflammation could affect
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General factors affecting drug metabolism: effect of physiological factors and disease 2

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