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1. Introduction
2. Neurodegenerative disorders
3. Neurodegenerative disorders - inclusion bodies
4. Fate of a protein in the cell
5. Mutations in UPS components and chaperones
6. The ubiquitin-proteasome system
7. Role of CHIP in protein degradation
8. The aggresome
9. Tracing aggresome formation
10. Microtubules important for aggresome formation
11. Protective role of the aggresome
12. Role of HDAC6 in aggresome formation
13. Molecular chaperones and neurodegeneration
14. Hsp70 overexpression and Kennedy's disease
15. Hsp70 overexpression in Drosophila
16. CHIP overexpression and Kennedy's disease
17. Chemical induction of heat-shock proteins
18. Stress and induction of heat-shock proteins
19. Heat shock response
20. Defects in chaperone system
21. Chaperones in Huntington's disease model
22. Heat shock response in polyQ-expressing cells
23. Defects in UPS
24. Measurements of proteasome activity in a cell
25. UPS activity inhibition in cells with aggresomes
26. Proteasome subunits and Hsp70 in PD brain
27. Chaperone system and UPS defects with aging
28. Aging signaling pathways
29. Decrease in chaperone expression upon aging
30. Decrease in proteasome activity upon aging
31. Generation of Ubb+1 frameshift mutation
32. Age-dependence of aggregation
33. Aggregation in long-lived C. elegans mutants
34. Neurological problems and aging

Topics Covered

• Aggregation of proteins associated with neurodegenerative disorders
• Mechanisms of aggresome formation
• Suppression of the heat shock response in aging and neurodegeneration
• Role of heat shock proteins in suppression of apoptosis and senescence programs

Links

Series:

• Molecular Chaperones

Categories:

• Biochemistry
• Cell Biology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Sherman, M. (2007, October 1). Molecular chaperones and handling of abnormal proteins in neurodegenerative disorders [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 22, 2024, from https://doi.org/10.69645/YKLD8439.
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Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. Michael Sherman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.