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Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- Depression
- Modelling aspects of depression
- Face, construct and predictive validity
- Other types of validity
- Testing for depressive-like behaviours
- Tests for behavioural despair
- Tests for anhedonia - sucrose preference test
- Tests for anhedonia - female urine sniff test
- Tests for anxiety behaviour
- Tests for anxiety and apathetic behaviour
- Tests for social behaviour
- Overview of methodological approaches
- Psychosocial stress
- Social defeat stress
- Other forms of psychosocial stress
- Witnessing psychosocial stress
- Neurobiological mechanisms - genetics
- DCC
- DCC and mIR-218
- DCC and mIR-218 in mouse models
- DCC knock-down models
- Sex as a biological variable
- Future directions
- Acknowledgments
- References
Topics Covered
- Depression
- Animal models
- Genetics
- Neurobiological mechanisms
- Psychosocial stress
- Types of validity
Talk Citation
Gururajan, A. (2020, November 30). Animal models for depression [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 8, 2024, from https://doi.org/10.69645/ICZR9636.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Anand Gururajan has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Neurology
Transcript
Please wait while the transcript is being prepared...
0:00
Hello everyone. My name is Anand,
and I'm a Research Fellow in the School of
Psychology at the University of Sydney in Australia.
For this Henry Stewart Talk,
I will be reviewing animal models for depression.
0:15
The outline of my talk is as follows.
I will first give an overview of depression.
Then I will talk about modeling aspects of depression,
and testing for depressive-like behaviors in rodents.
I will briefly touch on some of the strategies used to generate models for depression,
and then focus on stress as an inducing manipulation.
I'll talk about gaining insights into mechanisms of disease,
and sex as a biological variable before finishing off with some concluding thoughts.
At the end of this lecture,
I have included several references for further reading.
0:54
It goes without saying that with all that is going on in the world today,
the prevalence of depression is likely to increase in the years ahead.
Depression is a complex disorder,
characterized by various symptoms such as
decreased drive or loss of interests in pleasurable activities.
Antidepressants such as selective serotonin reuptake inhibitors are commonly prescribed,
but there is substantial variation in clinical efficacy.
There are some new entrance to the market that shows some promise such as ketamine,
but most newly developed drugs often have poor success rates.
The limited success in drug discovery is linked to
a limited understanding of the underlying biology of a complex disorder.
But it also reflects the difficulties in diagnosing depression.
Not all patients who are diagnosed present with
the same set of symptoms at the same point in time.
There is an urgent need for the next generation of antidepressant therapies,
that address these challenges,
and animal models will continue to play an important role.