Arylamine N-acetyltransferases 3

Published on October 1, 2007 Updated on July 28, 2016   19 min

Other Talks in the Series: Drug Metabolizing Enzymes

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Arylamine N-acetyltransferases. Part 3 I'm Edith Sim, and I have been working on these enzymes for over 20 years.
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So human NAT1, to recap, is widespread in tissue distribution, shows genetic polymorphism, N-acetylates p-aminobenzoic acid, and N-acetylates p-abaglu a folate catabolite. It hydrolyses acetylCoA in the presence of folate. It's clearly expressed in early development. It's over-expressed in ER positive breast cancer. And it's linked to folate and acetylCoA homeostasis.
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In order to explore this further, it was felt important to identify NAT1 specific inhibitors.
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This was done, again, you've seen this slide before, but just to emphasize, this was done to allow a library of over 5,000 compounds to be screened with recombinant specific enzymes including human NAT1.
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Arylamine N-acetyltransferases 3

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