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- Human Population Genetics: An Overview
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1. Modern human origins
- Prof. Richard Klein
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2. History and geography of human genetic diversity I
- Prof. Luigi Luca Cavalli-Sforza
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3. History and geography of human genetic diversity II
- Prof. Luigi Luca Cavalli-Sforza
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4. Cultural evolution
- Prof. Marcus Feldman
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5. The human genomes
- Prof. Gil McVean
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6. Human population structure
- Prof. Noah Rosenberg
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7. The signature of local adaptations in human polymorphism data
- Dr. Anna Di Rienzo
- The Human Genome Project
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8. The HapMap project
- Prof. Andrew Clark
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9. Major gene families in humans and their evolutionary history
- Prof. Yoshihito Niimura
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10. Evolution of human mitochondrial DNA variations
- Prof. Toomas Kivisild
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11. Ethical issues in human population genetics
- Prof. Henry Greely
- Important Phenotypic Phenomena
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12. Evolution: how genes and their variation got here
- Prof. Kenneth Weiss
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13. The genetic component to diabetes
- Dr. Nancy Cox
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14. Genetics of breast and ovarian cancer
- Prof. Jeffrey Weitzel
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15. Colorectal cancer and the rare variant hypothesis
- Prof. Sir Walter Bodmer
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16. Genetic diseases in the Jewish population
- Prof. Neil Risch
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17. The genetics of French Canadians
- Dr. Bernard Brais
- Dr. Bertrand Desjardins
- Prof. Damian Labuda
- Dr. Marc St-Hilaire
- Prof. Marc Tremblay
- Prof. Helene Vezina
- Historical and Geographical Genetic Variation
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18. Human genetic variation of Africa
- Prof. Joanna Mountain
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19. Genetics of Pakistani populations in an Asian and global context
- Prof. S. Qasim Mehdi
- Archived Lectures *These may not cover the latest advances in the field
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20. The genetics of breast and ovarian cancer
- Dr. Piri Welcsh
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21. Historical and geographical genetic variation: Europe
- Prof. Antonio Torroni
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22. Linguistic evolution
- Dr. Merritt Ruhlen
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23. Human microsatellite and minisatellite DNA polymorphisms
- Dr. James Weber
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24. Human population genetics: lifespan
- Prof. Kaare Christensen
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25. History and geography of human genetic diversity III
- Prof. Luigi Luca Cavalli-Sforza
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26. Major gene families in humans and their evolutionary history
- Prof. Yoshihito Niimura
- Prof. Masatoshi Nei
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27. Natural selection and sequence polymorphism
- Prof. Austin Hughes
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28. Human Y chromosome phylogenetics and phylogeography
- Prof. Peter Underhill
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29. The peopling of the Americas: new insights from genetic studies
- Dr. Theodore Schurr
Printable Handouts
Navigable Slide Index
- Introduction
- Understanding human traits' genetic basis
- Charles Darwin's tree of life
- Evolution by phenotype
- Visualizing evolution by phenotype
- The basic factors of evolutionary change
- Mutation
- Genetic drift
- 'Up or out' in small populations
- Change is slower in big populations
- Changes in a DNA sequence over time
- Bottleneck and founder effect
- Bottleneck and founder effects in Finland
- Finnish disease examples
- Geographic pattern of schizophrenia in Finland
- Bottlenecks and phenogenetic relationships
- A general age-area-frequency correlation
- Natural selection
- Types of natural selection
- Directional selection
- Balancing selection
- Gene flow
- Current human variation
- Geographic coherence in allele frequencies
- Global Y-chromosome haplotype distribution
- Global mtDNA haplotype distribution
- Genetic similarity between nearby populations
- World variation is a subset of African diversity
- Variability of Africans vs. other continents
- Determining similarity: examination of many loci
- Determining similarity: examination of SNPs
- Genetic similarity within and between continents
- Defining nearest relatives: single gene
- Defining nearest relatives: many genes
- Selection for skin pigmentation
- Global skin color distribution
- Human skin pigmentation evolution scenarios
- Global UV incidence pattern (today)
- Genotype-phenotype correlation
- Evolution of lighter skin in Europe and East Asia
- Adaptive evolution of human skin pigmentation
- A scenario for human skin color evolution
- Resistance to various forms of malaria
- Malarial intensity and red-cell genetic disorders
- Duffy null allele in malarial areas of Africa
- Hemoglobinopathies
- Beta-globin mutations in the malarial areas
- Beta-thalassemia mutants global distribution
- Alpha-thalassemia mutants global distribution
- Phenylketonuria (PKU)
- Location of PAH mutations in PKU pateints
- PKU mutations: many types
- Frequency distribution of 'PKU' alleles
- PKU as representative of 'simple' human traits
- PAH: each gene a quantitative trait?
- PKU incidence varies among populations
- Geographic variation in PAH alleles
- Same principles apply to more complex traits
- Deafness: pathways to similar phenotypes
- Multiple unilocus causation
- Mutations in some deafness-related genes
- Breast cancer
- Location and type of BRCA1 mutations
- Breast cancer and other complex traits
- Complex traits - many loci with many alleles
- Studies may identify various QTLs for a trait
- Predicting complex traits from genotypes
- Environmental effects
- Genetic' risk may depend on non-genetic factors
- Overall summary
- References
Topics Covered
- Evolution by phenotype
- Basic factors of evolutionary change
- Mutation
- Genetic drift
- Natural selection
- Gene flow
- Current human variation
- Human global Y chromosome haplotype distribution
- Human global mtDNA haplotype distribution
- Selection for skin pigmentation and human evolution
- Genetic variation and selection for resistance to various forms of malaria
- Phenylketonuria (PKU)
- Deafness
- Breast cancer
Talk Citation
Weiss, K. (2007, October 1). Evolution: how genes and their variation got here [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 26, 2024, from https://hstalks.com/bs/316/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Kenneth Weiss has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.